Evidence map›Paper›PMID 41704358›Full record

ArticleACS medicinal chemistry letters2026

Discovery of Dimer-Dependent Aminoacrylamide Molecular Glues for 14-3-3 Protein-Protein Interactions.

Paulo Pitasse-Santos, Marta Falcicchio, Rajdeep Sahota, Hadeeqa G Raza, Aneika C Leney, Richard H Cowan, Gareth Hall, Richard G Doveston

Abstract read
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In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paulo Pitasse-SantosSchool of Chemistry and Institute of Structural and Chemical Biology,University of Leicester, University Road, Leicester LE1 7RH, U.K.ORCID https://orcid.org/0000-0002-2720-2951
Marta FalcicchioSchool of Chemistry and Institute of Structural and Chemical Biology,University of Leicester, University Road, Leicester LE1 7RH, U.K.ORCID https://orcid.org/0000-0001-9301-3035
Rajdeep SahotaSchool of Chemistry and Institute of Structural and Chemical Biology,University of Leicester, University Road, Leicester LE1 7RH, U.K.
Hadeeqa G RazaSchool of Chemistry and Institute of Structural and Chemical Biology,University of Leicester, University Road, Leicester LE1 7RH, U.K.
Aneika C LeneySchool of Bioscience, University of Birmingham, Edgbaston, Birmingham, B15 2TT, U.K.ORCID https://orcid.org/0000-0002-2066-4950
Richard H CowanSchool of Biological Sciences and Institute of Structural and Chemical Biology,University of Leicester, University Road, Leicester, LE1 7RH, U.K.
Gareth HallSchool of Biological Sciences and Institute of Structural and Chemical Biology,University of Leicester, University Road, Leicester, LE1 7RH, U.K.
Richard G DovestonSchool of Chemistry and Institute of Structural and Chemical Biology,University of Leicester, University Road, Leicester LE1 7RH, U.K.ORCID https://orcid.org/0000-0002-7399-9607

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular glues (MGs) offer a promising strategy for stabilizing protein-protein interactions (PPIs), particularly within the 14-3-3 protein family, which regulates diverse cellular processes and is implicated in many disease pathways. This study reports on the discovery of an aminoacrylamide MG (

Indexed as

14−3−3 proteinsdimeric interfaceMolecular glueprotein−protein interactions

Identifiers

PMID41704358
PMCPMC12907963

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.