Evidence map›Paper›PMID 41704776›Full record

ReviewiScience2026

From lipid function to dysfunction: Very long-chain fatty acids as emerging regulators of neuroinflammatory pathways.

Ranjan Kumar Sahu, Yunseon Yang, Hyung-Lok Chung

Abstract readReview
In one paragraph

Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ranjan Kumar SahuDepartment of Neurology, Houston Methodist Research Institute, Houston, TX, USA.
Yunseon YangDepartment of Neurology, Houston Methodist Research Institute, Houston, TX, USA.
Hyung-Lok ChungDepartment of Neurology, Houston Methodist Research Institute, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipids are key structural and functional components of the brain, essential for cellular integrity and homeostasis. They regulate signaling pathways driving neuroinflammation, a key factor in many neurological disorders. We review the interplay between lipid metabolism and neuroinflammation, with a focus on very long-chain fatty acids, that are crucial for membrane integrity and of myelin formation. Insights from human genetic disorders highlight how lipid metabolic dysfunction triggers neuroinflammatory cascade. Studies in

Indexed as

biochemistrybiological sciencesnatural sciences

Identifiers

PMID41704776
PMCPMC12907123

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.