ArticleFrontiers in microbiology2025
Modulation of gut microbiota and short-chain fatty acids by probiotics attenuates inflammation in endometriosis.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Oxidative Stress-Gut Microbiome Crosstalk: Intestinal Redox Imbalance and Probiotics Therapeutic Potential.Antioxidants (Basel, Switzerland) · 2026Review
- Orchestrating the gut microbiota-mitochondrial-immune axis in gynecological diseases: mechanisms and dual-targeting therapeutic strategies.Frontiers in reproductive health · 2026Review
- From gut-reproductive microbiota to ferroptosis: a comprehensive insight into the molecular-pathogenicity of endometriosis.Frontiers in immunology · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: This study investigated whether probiotics alleviate Endometriosis (EMs)-related inflammation by modulating the gut microbiota and short-chain fatty acids (SCFAs). Methods: An endometriosis model was established in SD rats, which were randomly divided into a normal diet group (NCD) and a probiotic group (NCD_Pro), with four rats per group. After a 4-week dietary intervention, serum and fecal samples were collected. Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 levels were measured by ELISA, gut microbiota composition was analyzed via 16S rRNA sequencing, and fecal levels of nine SCFAs were quantified using GC-MS. Results: Probiotic supplementation significantly reduced serum levels of TNF-α and IL-6 ( Conclusion: Probiotic intervention alleviates systemic inflammation in endometriosis by reshaping the gut microbiota structure, enhancing microbial network stability, and modulating the SCFA metabolism. Our findings underscore the role of the gut microbiota-metabolism-immunity axis in EMs pathophysiology and point to 4-MVA as a hypothesis-generating candidate metabolite that requires further validation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.