Evidence map›Paper›PMID 41705118›Full record

ArticleFrontiers in veterinary science2025

Propolis as an alternative remedy for the treatment of subclinical mastitis in dairy cows.

Zoja Mikniene, Grazvydas Puska, Mindaugas Liaudanskas, Jurate Siugzdaite, Loreta Kubiliene, Jurate Rudejeviene, Vaidotas Zvikas, Neringa Sutkeviciene, Ona Ragazinskiene, Sonata Trumbeckaite

Abstract read
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zoja MiknieneVeterinary Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Grazvydas PuskaVeterinary Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Mindaugas LiaudanskasMedicine Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Jurate SiugzdaiteVeterinary Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Loreta KubilieneMedicine Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Jurate RudejevieneVeterinary Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Vaidotas ZvikasMedicine Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Neringa SutkevicieneVeterinary Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Ona RagazinskieneKaunas Botanical Garden of Vytautas Magnus University, Kaunas, Lithuania.
Sonata TrumbeckaiteMedicine Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Subclinical mastitis is a widespread condition in dairy cows, often treated with antibiotics. Due to rising antimicrobial resistance, natural alternatives like propolis are gaining interest. Objectives: To evaluate the antibacterial efficacy of 5 and 10% propolis alginate emulsions in cows with subclinical mastitis and assess their effects on milk quality and systemic biomarkers. Methods: Ten dairy cows diagnosed with subclinical mastitis were divided into two treatment groups (5 and 10% propolis emulsions). Emulsions were administered intramammarily and orally for 5 days. Bacterial load in milk, milk composition, blood biochemical and immunological parameters, phenolic compound profiles, and antioxidant activity were analysed using standard microbiological and biochemical methods. Results: The 5% emulsion reduced bacterial load by 2.27 log CFU/ml, outperforming the 10% emulsion (0.89 log CFU/ml; Conclusion: A 5% propolis alginate emulsion was more effective than the 10% formulation in reducing bacterial counts and improving immunological and biochemical profiles. These findings support propolis as a promising natural alternative for treating subclinical mastitis, warranting further investigation into optimal formulations and long-term safety.

Indexed as

antioxidant activitycattleflavonoidsphenolic acidspropolissubclinical mastitis

Identifiers

PMID41705118
PMCPMC12907757

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.