ReviewFrontiers in medicine2025
Mechanistic insights into non-coding RNAs regulate autophagy in chondrocytes and their contribution to osteoarthritis.
Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Osteoarthritis (OA), a chronic degenerative joint disease, arises from a confluence of factors including aging, mechanical injury, and obesity. Autophagy, a fundamental cellular process involving the degradation and recycling of cellular components, plays a critical role in chondrocyte homeostasis and survival under stress. Non-coding RNAs (ncRNAs), a diverse class of RNA molecules with no protein-coding potential, exert significant influence on gene expression through post-transcriptional and epigenetic mechanisms. Growing evidence suggests a crucial interplay between ncRNAs, autophagy, and OA pathogenesis. This review summarizes the multifaceted role of autophagy in OA chondrocytes and delves into the regulatory mechanisms of ncRNAs on OA-associated autophagy, aiming to elucidate the intricate pathological network underlying OA development and identify novel therapeutic targets.
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