The relationship between arthritis and mild cognitive impairment in different obese metabolic heterogeneity populations-the mediating role of depression.

Chen Li, Yitie Chang, Jingxuan Cui, Zhetian Wang, Linru Zeng

Abstract read

In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chen Li *Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.

Yitie Chang *Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.

Jingxuan Cui *The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.

Zhetian WangJiangnan Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.

Linru ZengJiangnan Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The purpose of this study is to investigate whether depression may mediate the association between arthritis and mild cognitive impairment (MCI) in diverse BMI-based obese populations with multi-parameter metabolic signatures including insulin resistance, inflammatory markers, and lipid metabolism indices. Methods: The relationships between arthritis, MCI, and depression were investigated in a large-scale study that used logistic regression, subgroup analyses, and mediation analyses. The participants in the study came from obese individuals classified into distinct metabolic obesity phenotypes based on insulin resistance, inflammatory markers, and lipid metabolism. Results: Arthritis is positively correlated with MCI (OR = 1.86, 95% CI = 1.60-2.17, Conclusion: The results of this study highlight the potential clinical value of an integrated management strategy combining metabolic regulation, anti-inflammatory treatment, and routine depression screening in obese patients with arthritis to reduce the risk of cognitive decline.

Indexed as

arthritisdepressionmediationmetabolic heterogeneitymild cognitive impairmentobesity

Identifiers

PMID41705203

DOI10.3389/fnut.2026.1653086

PMCPMC12908586

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.