Evidence map›Paper›PMID 41705294›Full record

ArticleClinical and translational medicine2026

Decreased adipokine CTRP4 in CAD patients: CTRP4 attenuates atherosclerosis via inhibition of RAGE and TLR4.

Xinyi Shu, Feifei Li, Jiawei Chen, Xinrui Wu, Leyuan Tao, Abulikemu Amuti, Shuai Chen, Jinwei Quan, Jingmeng Liu, Yipaerguli Maimati and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xinyi ShuDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Feifei LiDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Jiawei ChenDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Xinrui WuDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Leyuan TaoDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Abulikemu AmutiDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Shuai ChenDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.ORCID https://orcid.org/0000-0002-8387-2335
Jinwei QuanDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Jingmeng LiuDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Yipaerguli MaimatiDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Fenghua DingDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Ying ShenDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.ORCID https://orcid.org/0009-0005-4179-0955
Qiujing ChenInstitute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Weifeng ShenDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Ruiyan ZhangDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Yang DaiDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Xiaoqun WangDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.ORCID https://orcid.org/0000-0003-0956-8041
Lin LuDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.

Funding

National Natural Science Foundation of China 81770430National Natural Science Foundation of China 82070358National Natural Science Foundation of China 82170423
6 · The paper itself

Abstract

backgroundC1q/TNF-related proteins (CTRPs) belong to the adipokine family. Here, we aimed to assess the relation of CTRP4 levels in serum and perivascular adipose tissue (PVAT) with coronary artery disease (CAD), and investigate the effect of CTRP4 on atherosclerosis and the underlying mechanisms.

methodsCTRP4 levels were examined in serum and epicardial adipose tissue (a major PVAT) from patients with CAD. Atherosclerotic lesions were analysed in CTRP4

resultsCTRP4 levels were lower in serum and epicardial adipose tissue of patients with CAD compared to non-CAD controls. CTRP4 knockout promoted atherosclerosis in ApoE

conclusionsDecreased CTRP4 levels in serum and epicardial adipose tissue are associated with CAD in patients. CTRP4 deficiency promotes the development of atherosclerosis in ApoE

Indexed as

AdipokinesAtherosclerosisCoronary Artery DiseaseReceptor for Advanced Glycation End ProductsToll-Like Receptor 4AnimalsFemaleHumansMaleMiceMice, KnockoutMiddle AgedAdipokinesReceptor for Advanced Glycation End ProductsTLR4 protein, humanToll-Like Receptor 4atherosclerosisCTRP4RAGETLR4

Identifiers

PMID41705294
PMCPMC12914348

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.