ArticleBiomaterials science2026
Clickable polyamidosaccharides: accessing bottlebrush inspired hyaluronic acid glycopolymers for CD44 targeting of breast cancer cells.
Article in Biomaterials science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Hyaluronic acid (HA) binds the transmembrane glycoprotein cluster of differentiation-44 (CD44), a highly expressed surface receptor that plays a critical role in tumor growth, invasion, and metastasis. Approaches to target CD44 utilize biologically sourced HA which inherently suffers from molecular weight (MW) heterogeneity and biological contaminants. Fully synthetic approaches to HA are attractive and circumvent these biological contaminants; however, readily accessing oligomers of six monosaccharides or more, as is required for CD44 binding, is challenging. To this end, we report the synthesis of glycopolymers functionalized with HA disaccharide pendant chains. These well-defined and regioselective polymers consist of glucose monomers linked
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