Multifocal Benign Metastasizing Pleomorphic Adenoma Presenting as a Lymphoma: An Atypical Clinical Picture Demystified by an Unusual PLAG1 Gene Rearrangement Detected on RNA Next Generation Sequencing.

Poorva Singh, Spencer M Erickson, Kathryn Baxstrom, Paari Murugan

Abstract readCase Reports

In one paragraph

Article in Diagnostic cytopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Poorva SinghDepartment of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-9136-2274

Spencer M EricksonInternal Medicine Residency Program, Department of Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.

Kathryn BaxstromHealthPartners Cancer Center at Regions Hospital, Saint Paul, Minnesota, USA.

Paari MuruganDepartment of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 57-year-old female presented to urgent care with exertional dyspnea, back pain, and several months of night sweats. Imaging showed an anterior mediastinal mass with concurrent hepatic and vertebral lesions, raising suspicion for a hematolymphoid malignancy. Fine needle aspiration (FNA) and needle core biopsies were obtained from the liver lesion, with morphologic features compatible with pleomorphic adenoma (PA) without evidence of malignant or high-grade cytologic features, adding to the complexity of interpretation. Revisiting her history revealed a diagnosis of a benign salivary gland tumor in the left parotid, which was surgically removed almost 40 years ago. This piece of clinical information put the morphology into perspective and subsequent molecular testing detected an unusual PLAG1 gene rearrangement, confirming the diagnosis of a benign metastasizing PA in this unique case.

Indexed as

Adenoma, PleomorphicDNA-Binding ProteinsLiver NeoplasmsLymphomaSalivary Gland NeoplasmsSpinal NeoplasmsDiagnosis, DifferentialFemaleGene RearrangementHumansLiverMiddle AgedNeoplasm MetastasisSequence Analysis, RNADNA-Binding ProteinsPLAG1 protein, humanbenign metastasizingcytomorphologyNGSPLAG1pleomorphic adenoma

Identifiers

PMID41705583

DOI10.1002/dc.70098

PMCPMC13047302

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.