Evidence map›Paper›PMID 41706098›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2026

Impacts of prenatal resiquimod exposure during late gestation on rat offspring development and behavior.

Monique Martinez, Stuart A Tobet, Taben M Hale

Abstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Monique MartinezDepartment of Basic Medical Sciences, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, United States.ORCID 0000-0002-6005-8509
Stuart A TobetInnovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States.ORCID 0000-0002-1615-7331
Taben M HaleDepartment of Basic Medical Sciences, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, United States.ORCID 0000-0002-5066-1216

Funding

Sex Differences in Major Depression, Part II: Impact of Prenatal Immune, Autonomic and Neurovascular FunctionU54MH118919 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Ronald G. Garcia · 2020 to 2026
$12.7M
PHYSIOLOGYT32HL007249 · NHLBI · UNIVERSITY OF ARIZONA · PI Brett A Colson, JOHN P KONHILAS · 1985 to 2026
$12.5M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32-HL007249HHS | NIH | National Institute of Mental Health (NIMH) U54-MH118919HHS | NIH | National Institute of Mental Health (NIMH) U54-MH118919-04S3NHLBI NIH HHS T32 HL007249NIMH NIH HHS U54 MH118919
6 · The paper itself

Abstract

Maternal stress during pregnancy causes changes in circulating glucocorticoids and inflammatory cytokines that can alter fetal development. Prior studies have shown that prenatal dexamethasone impacts fetal brain development, increases anxiety-like behavior, and dysregulates neuroendocrine and autonomic function in adult rat offspring. Resiquimod (RQ) activates toll-like receptor 7, causing immune activation. The current study investigated the impact of RQ-induced maternal immune activation during late gestation on rat offspring development and behavior. Pregnant dams were weighed daily. On

Indexed as

Behavior, AnimalImidazolesPrenatal Exposure Delayed EffectsAnimalsAnxietyDevelopmental Origins of Health and DiseaseFemaleGestational AgeMaleMaternal BehaviorPregnancyRatsRats, Sprague-DawleySexual MaturationToll-Like Receptor AgonistsImidazolesresiquimodToll-Like Receptor Agonistsanimal modelanxietymaternal immune activationpubertyresiquimod

Identifiers

PMID41706098
PMCPMC13046330

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.