Evidence map›Paper›PMID 41706260›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2026

Metagenomic analysis of the intragastric and oral microbiome associated with gastric carcinogenesis after Helicobacter pylori eradication.

Masanori Matsumoto, Akiko Shiotani, Motoyasu Osawa, Osamu Handa, Hiroshi Matsumoto, Eiji Umegaki, Hideo Yonezawa, Takako Osaki

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Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Masanori MatsumotoDepartment of Gastroenterology and Hepatology, Kawasaki Medical School, 577, Matsushima, Kurashiki-city, Okayama, 701-0192, Japan.
Akiko ShiotaniDepartment of Gastroenterology and Hepatology, Kawasaki Medical School, 577, Matsushima, Kurashiki-city, Okayama, 701-0192, Japan. shiotani@med.kawasaki-m.ac.jp.ORCID 0000-0002-0393-2642
Motoyasu OsawaDepartment of Gastroenterology and Hepatology, Kawasaki Medical School, 577, Matsushima, Kurashiki-city, Okayama, 701-0192, Japan.
Osamu HandaDepartment of Gastroenterology and Hepatology, Kawasaki Medical School, 577, Matsushima, Kurashiki-city, Okayama, 701-0192, Japan.
Hiroshi MatsumotoDepartment of Gastroenterology and Hepatology, Kawasaki Medical School, 577, Matsushima, Kurashiki-city, Okayama, 701-0192, Japan.
Eiji UmegakiDepartment of Gastroenterology and Hepatology, Kawasaki Medical School, 577, Matsushima, Kurashiki-city, Okayama, 701-0192, Japan.
Hideo YonezawaDepartment of Microbiology, Tokyo Dental College, 2-9-18, Kanda Misakicho, Chiyoda-ku, Tokyo, 101-0061, Japan.
Takako OsakiDepartment of Preventive Medicine, Kyorin University School of Medicine, 20-2 Shin-Kawa 6-chome, Mitaka-shi, Tokyo, 181-8611, Japan.

Funding

Kawasaki Medical School Research Project Grant
6 · The paper itself

Abstract

backgroundFew reports have investigated bacterial microbiome in relation to gastric cancer after eradication of Helicobacter pylori (H. pylori). We aimed to conduct a genetic analysis of the gastric and oral microbiome, to identify its association with development of gastric cancer after H. pylori eradication.

methodsThe patients with prior endoscopic submucosal dissection (ESD) history after eradication (cancer patients) and control patients after eradication who underwent upper gastrointestinal endoscopy at Kawasaki Medical School Hospital from May 2021 to March 2023 were enrolled. Saliva and gastric mucus samples were collected and profiled by 16S rRNA gene amplicon sequencing.

resultsThe subjects consisted of 24 cancer patients and 27 controls. The abundance of the genus Rothia in gastric mucus of the cancer patients was significantly higher compared to the controls. Conversely, the genus Parvimonas was significantly less abundant in the cancer patients. These differences in salivary samples between the two groups were not observed. The abundance of the genus Parvimonas in the gastric mucous was associated with the gastric atrophy, but genus Rothia was not.

conclusionsGenus Rothia may have some influence on carcinogenesis following H. pylori eradication.

Indexed as

Helicobacter InfectionsHelicobacter pyloriMicrobiotaMouthStomach NeoplasmsAgedCarcinogenesisCase-Control StudiesFemaleGastric MucosaHumansMaleMetagenomicsMiddle AgedRNA, Ribosomal, 16SSalivaRNA, Ribosomal, 16SAfter eradicationGastric cancerGastric mucusRothiaSaliva

Identifiers

PMID41706260

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.