Evidence map›Paper›PMID 41706396›Full record

ReviewClinical reviews in allergy & immunology2026

Heterogeneity in Atopic Dermatitis: Ethnic, Anatomical Site, and Age-related Variations.

Yixuan Liu, Yizhen Li, Liangliang Sun, Hao Wu, Huibin Yin, Haihong Qin, Chaoying Gu, Christopher Chang, Wei Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical reviews in allergy & immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yixuan Liu *Department of Dermatology, Shanghai Institute of Dermatology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Yizhen Li *Department of Dermatology, Shanghai Institute of Dermatology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Liangliang Sun *Peking University First Hospital, Beijing, China.
Hao WuDepartment of Dermatology, Shanghai Institute of Dermatology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Huibin YinDepartment of Dermatology, Shanghai Institute of Dermatology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Haihong QinDepartment of Dermatology, Shanghai Institute of Dermatology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Chaoying GuDepartment of Dermatology, Shanghai Institute of Dermatology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Christopher ChangDivision of Immunology, Allergy and Rheumatology, Joe DiMaggio Children's Hospital, Memorial Healthcare System, Hollywood, FL, 33021, USA. chrchang@mhs.net.
Wei LiDepartment of Dermatology, Shanghai Institute of Dermatology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China. liweiderma@fudan.edu.cn.

Funding

Clinical Research Funding of Shanghai Municipal Health Commission 202440121Key Project of the Innovation Program of Shanghai Municipal Education Commission 2021-01-07-00-07-E00078National Natural Science Foundation of China 82273531Program of Shanghai Academic/Technology Research Leader 23XD1400400Shanghai Municipal Commission of Science and Technology 23Y31920300
6 · The paper itself

Abstract

Atopic dermatitis (AD) is a chronic, systematic inflammatory dermatosis with a high prevalence worldwide, characterized by multiple heterogeneities. Recent studies have highlighted variations in the incidence and manifestation of AD among different ethnic populations due to genetic and immunological differences. The severity of AD also varies by anatomical sites, influenced by factors such as regional skin microenvironment, microbiome-immune interaction, and environmental exposure. Notably, head and neck dermatitis (HND) is a refractory phenotype of AD, which responds less well to conventional and novel systemic treatment. Furthermore, distinct susceptibility factors exist across age groups, including food allergies in infants and young children, psychological stress in adults, and aging-related AD in the elderly. The heterogeneity of AD requires further exploration of the pathogenesis in different states, which also poses a significant challenge for therapy. This review synthesizes current evidence on AD heterogeneity, elucidating variations across ethnicities, anatomical sites, and age groups to guide the development of precision treatment.

Indexed as

Dermatitis, AtopicSkinAge FactorsAgingEthnicityGenetic Predisposition to DiseaseHumansAtopic dermatitisHead and neck dermatitisHeterogeneityPrecision treatment

Identifiers

PMID41706396

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.