Hypoxia-induced production of the cyclolipodepsipeptide BE-43547 by

Marie Selch Tvilum, Camilla Bak Nielsen, Iben Steensgaard, Thomas Bjørnskov Poulsen, Mogens Johannsen, Thomas Tørring

Abstract read

In one paragraph

Article in Microbiology (Reading, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marie Selch TvilumDepartment of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.

Camilla Bak NielsenDepartment of Forensic Medicine, Aarhus University, Aarhus, Denmark.

Iben SteensgaardDepartment of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.

Thomas Bjørnskov PoulsenDepartment of Chemistry, Aarhus University, Aarhus, Denmark.

Mogens JohannsenDepartment of Forensic Medicine, Aarhus University, Aarhus, Denmark.

Thomas TørringDepartment of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The urgent need for new antibiotics emphasizes the importance of investigating the many biosynthetic gene clusters that remain silent under standard culture conditions and of assigning functions to the many natural products already discovered. Conventional approaches, such as altering the screening medium composition or culture conditions to trigger production, are often labourious and disconnected from the function of the natural products. In this study, we combine antimicrobial assays and the controlled culture conditions available in benchtop bioreactors to demonstrate that BE-43547, a natural product that exists as a mixture of congeners, is selectively active against Gram-positive bacteria growing anaerobically. Furthermore, we show that the producing organism

Indexed as

Anti-Bacterial AgentsDepsipeptidesMicromonosporaOxygenAnaerobiosisGram-Positive BacteriaMicrobial Sensitivity TestsAnti-Bacterial AgentsDepsipeptidesOxygenantibioticsbiosynthesishypoxiasecondary metabolites

Identifiers

PMID41706591

DOI10.1099/mic.0.001662

PMCPMC12916061

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.