ArticlePloS one2026
Disproportionate use of polysubstance combinations varies by sexual identity among US adults.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polysubstance use is a major public health concern affecting lesbian, gay, and bisexual (LGB) adults, especially bisexual female adults. This study aims to identify the commonly used polysubstance combinations by LGB adults in the past 30 days and to determine whether these combinations differ by sexual identity and sex. Our analytic sample consisted of NSDUH 2021 and 2022 (n = 66,634 adults; 8.59% LGB adults). We used survey-weighted multinomial logistic regression models to assess the polysubstance combinations by sex. The most used substances were binge alcohol drinking, cannabis, cigarettes, and nicotine vape. Bisexual female adults used most of the assessed polysubstance combinations that included binge alcohol drinking, cannabis, or both, often involving three or four substances. Sex differences among the polysubstance combinations vary among heterosexual and bisexual adults but not among gay/lesbian adults. Public health strategies must consider the specific sexual identity, sex, and the types of substance combinations involved.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.