ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
PRELID1 and VDAC3 Coordinate a Senescence-Like State in Germinal Center B Cells to Promote IL-7-Driven Antitumor Immunity in Colorectal Cancer.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Colorectal cancer (CRC) is characterized by an immune-suppressive microenvironment that facilitates to tumor progression and immunotherapy resistance. Emerging evidence indicates that tumor-infiltrating B cell subsets play dual roles in modulating antitumor immunity. However, the mechanisms underlying their regulatory functions remain poorly understood. In this study, we constructed single-cell transcriptomic analyses and a Bgc adoptive transfer model in B cell-deficient mice, performing multifaceted validation to confirm that targeting the PRELID1-VDAC3-IL-7 axis in senescence-like germinal center B cells enhances sensitivity to anti-PD-L1 immunotherapy. Mechanistically, we identify a senescence-like state in germinal center B cells (Bgc) that enhances antitumor immunity in CRC by promoting Interleukin-7 (IL-7) secretion and alleviating CD8
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