Evidence map›Paper›PMID 41706850›Full record

ReviewScience advances2026

Redox therapy for neuropsychiatric disorders: Molecular mechanisms and biomarker development.

Kyle W Cuklanz, Abigail Stein, Virginie-Anne Chouinard, Dost Ongur, Fei Du

Abstract readReview
In one paragraph

Review in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kyle W CuklanzPsychotic Disorders Division, McLean Hospital, Belmont, MA 02478, USA.ORCID 0009-0008-8639-0498
Abigail SteinPsychotic Disorders Division, McLean Hospital, Belmont, MA 02478, USA.ORCID 0000-0001-6246-6947
Virginie-Anne ChouinardPsychotic Disorders Division, McLean Hospital, Belmont, MA 02478, USA.
Dost OngurPsychotic Disorders Division, McLean Hospital, Belmont, MA 02478, USA.
Fei DuPsychotic Disorders Division, McLean Hospital, Belmont, MA 02478, USA.ORCID 0000-0002-9549-4255

Funding

Effects of Orally Administered Nicotinamide Riboside on Bioenergetic Metabolism, Oxidative Stress and Cognition in Mild Cognitive Impairment and Mild Alzheimer's DementiaR01AG066670 · NIA · MCLEAN HOSPITAL · PI DU, FEI, FORESTER, BRENT PETER · 2020 to 2024
$4.0M
Molecular Mechanisms of Aging in Schizophrenia: Implications of Bioenergetic Metabolism and Redox BiologyR01MH135093 · NIMH · MCLEAN HOSPITAL · PI FEI DU, Dost Ongur · 2024 to 2026
$2.5M
Molecular Mechanisms and Biomarkers for Disease Progression from Prodrome to Early PsychosisR01MH114982 · NIMH · MCLEAN HOSPITAL · PI DU, FEI, ONGUR, DOST · 2019 to 2023
$2.4M
NIA NIH HHS R01 AG066670NIMH NIH HHS R01 MH114982NIMH NIH HHS R01 MH135093
6 · The paper itself

Abstract

Redox dysregulation, characterized by an imbalance in the NAD

Indexed as

BiomarkersMental DisordersAlzheimer DiseaseAnimalsEnergy MetabolismHumansMitochondriaNADOxidation-ReductionOxidative StressSchizophreniaBiomarkersNAD

Identifiers

PMID41706850
PMCPMC12915611

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.