Evidence map›Paper›PMID 41707069›Full record

ReviewMicrobial biotechnology2026

Next-Generation Microencapsulation Technologies for Probiotic Protection and Precision Delivery.

Yixin Zhu, Longxian Lv, Bingbing Du, Mingrui Zhao

Abstract readReview
In one paragraph

Review in Microbial biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Dietary Encapsulation of a NovelAntioxidants (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yixin ZhuJinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong, China.
Longxian LvState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Bingbing DuJinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong, China.
Mingrui ZhaoDepartment of Obstetrics and Gynecology, The First Clinical School of Medicine, Nanjing Medical University, Nanjing, China.

Funding

Central Guidance Fund for Local Science and Technology Development 2024ZY01054Fundamental Research Funds for the Central Universities 2022ZFJH003National Key Research and Development Program of China 2022YFC2304500National Key Research and Development Program of China 2023YFC2506000Research Project of Jinan Microecological Biomedicine Shandong Laboratory JNL-2022009BResearch Project of Jinan Microecological Biomedicine Shandong Laboratory JNL-2022047DShandong Provincial Laboratory Project SYS202202
6 · The paper itself

Abstract

Probiotics offer well-documented benefits, including improved gastrointestinal function, microbiota modulation, and immune enhancement. However, their therapeutic potential is limited by poor survival during oral delivery due to gastric acid, bile salts, and pathological gut conditions. Microencapsulation has emerged as a transformative strategy to enhance probiotic viability by shielding them from environmental stressors. This review comprehensively examines cutting-edge microencapsulation materials and innovative techniques that improve probiotic stability under thermal, oxidative, and gastrointestinal stresses. We highlight advanced delivery systems, such as pH-responsive and inflammation-targeted microcapsules, which enable precise intestinal release and enhanced colonisation. Additionally, we critically assess safety considerations and industrial scalability challenges, emphasising the need for biocompatible materials and cost-effective production. By integrating recent breakthroughs with practical applications, this review underscores the potential of next-generation microencapsulation to enable safer, more efficient, and personalised probiotic therapies.

Indexed as

Drug CompoundingDrug Delivery SystemsProbioticsCapsulesHumansCapsulesenvironmental stressmicroencapsulationprobioticstargeted drug delivery

Identifiers

PMID41707069
PMCPMC12916023

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.