Evidence map›Paper›PMID 41707108›Full record

ArticleThe Journal of infectious diseases2026

Association of Plasma Biomarkers of Immunothrombosis With Death in Patients With Coronavirus Disease 2019 on Extracorporeal Membrane Oxygenation.

Andrew P Platt, Viviane Callier, Alison Grazioli, Zonghui Hu, Sydney R Stein, Megan G Anders, Seth Warner, Emily Ricotta, Trevor M Stantliff, Jocelyn Wu and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Andrew P PlattEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0001-8481-114X
Viviane CallierClinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Rockville, Maryland, USA.ORCID 0000-0002-9754-560X
Alison GrazioliR Adams Cowley Shock Trauma Center, Department of Medicine and Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Zonghui HuBiostatistics Research Branch, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland, USA.
Sydney R SteinEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Megan G AndersDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Seth WarnerEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0009-0001-4571-9188
Emily RicottaEpidemiology and Data Management Unit, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0001-9928-8275
Trevor M StantliffEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-2621-3111
Jocelyn WuUniversity of Maryland Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Nicole HaysUniversity of Maryland Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Katherine RajaUniversity of Maryland Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-8108-5904
Ryan CurtoUniversity of Maryland Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Madeleine PurcellUniversity of Maryland Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-5753-8029
Shreya SingireddyUniversity of Maryland Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Douglas TranDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Raymond RectorDepartment of Peri-operative Services, University of Maryland Medical Center, Baltimore, Maryland, USA.
Sabrina ChoDepartment of Peri-operative Services, University of Maryland Medical Center, Baltimore, Maryland, USA.
Katelyn WagnerDepartment of Peri-operative Services, University of Maryland Medical Center, Baltimore, Maryland, USA.
Sabrina C RamelliLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0001-5428-2814
Marcos J Ramos-BenitezEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0001-9445-3294
James DickeyEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Jeffrey R StrichEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Kevin M VannellaEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Miranda GibbonsDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Peter RockDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-2250-5926
Ali TabatabaiR Adams Cowley Shock Trauma Center, Department of Medicine and Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5325-4907
Michael T McCurdyUniversity of Maryland Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-5319-0475
Thomas ScaleaR Adams Cowley Shock Trauma Center, Department of Surgery and Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Robert ChristensonDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Mohammad M SajadiInstitute of Human Virology, Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Daniel HerrR Adams Cowley Shock Trauma Center, Department of Medicine and Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-8533-9000
Bradley TaylorDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Kapil SahariaInstitute of Human Virology, Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5116-0042
Ronson J MadathilCardiovascular Surgery Department, Wellspan Health York Hospital, York, Pennsylvania, USA.
Joseph RabinR Adams Cowley Shock Trauma Center, Department of Surgery and Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-4369-1932
Dean FollmannBiostatistics Research Branch, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland, USA.
Daniel S ChertowEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-1675-1728

Funding

NCI NIH HHS HHSN261201500003CNCI NIH HHS HHSN261201500003INIHNIH Clinical Center
6 · The paper itself

Abstract

backgroundCritical illness in coronavirus disease 2019 may require extracorporeal membrane oxygenation support. We quantified immunothrombotic markers in patients with COVID-19 receiving ECMO and evaluated their predictive capacity for death.

methodsWe performed a retrospective analysis of 74 consecutive patients with COVID-19 on ECMO at a single academic medical center between March 2020 and February 2021. Severe acute respiratory syndrome coronavirus-2 nucleocapsid RNA and 16 immunothrombotic biomarkers were longitudinally quantified and their trajectories were used to predict death and decannulation across multiple models.

resultsMale sex, smoking, serum bilirubin levels, and low partial arterial oxygen pressure-fraction of inspired oxygen ratio were associated with increased risk of death. Plasma levels of 10 immunothrombotic markers were significantly elevated in fatal cases and some were associated with an increased hazard of death (eg, interleukin 8, von Willebrand factor) or decreased hazard for decannulation (eg, angiopoietin 2, interleukin 1β) when adjusting for sex, smoking status, and time to cannulation. Predictive models incorporating biomarkers were superior to demographics alone and equivalent to models including clinical information.

conclusionsWe found that male sex, smoking, and select clinical variables and immunothrombotic markers were risk factors for death in patients with COVID-19 on ECMO informing pathogenesis and prognostication of severe COVID-19.

Indexed as

BiomarkersCOVID-19Extracorporeal Membrane OxygenationThrombosisAdultFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsSARS-CoV-2BiomarkersbiomarkersCOVID-19ECMOimmunothrombosis

Identifiers

PMID41707108
PMCPMC13431774

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.