Evidence map›Paper›PMID 41707438›Full record

ArticleSchizophrenia research2026

Novel positive allosteric modulators of alpha 5 subunit-containing GABA

Daniela L Uliana, Mariana O Popa, Michael Paradowski, Karen T Elvers, Marcus Hanley, Alex Baldwin, John R Atack, Anthony A Grace

Abstract read
In one paragraph

Article in Schizophrenia research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniela L UlianaDepartments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: uliana@pitt.edu.
Mariana O PopaMedicines Discovery Institute, Cardiff University, Park Place, CF10 3AT, Cardiff, Wales, United Kingdom; Draig Therapeutics, Sbarc Building, Maindy Road, CF24 4HQ, Cardiff, Wales, United Kingdom.
Michael ParadowskiMedicines Discovery Institute, Cardiff University, Park Place, CF10 3AT, Cardiff, Wales, United Kingdom; Draig Therapeutics, Sbarc Building, Maindy Road, CF24 4HQ, Cardiff, Wales, United Kingdom.
Karen T ElversMedicines Discovery Institute, Cardiff University, Park Place, CF10 3AT, Cardiff, Wales, United Kingdom.
Marcus HanleyMedicines Discovery Institute, Cardiff University, Park Place, CF10 3AT, Cardiff, Wales, United Kingdom.
Alex BaldwinMedicines Discovery Institute, Cardiff University, Park Place, CF10 3AT, Cardiff, Wales, United Kingdom.
John R AtackMedicines Discovery Institute, Cardiff University, Park Place, CF10 3AT, Cardiff, Wales, United Kingdom; Draig Therapeutics, Sbarc Building, Maindy Road, CF24 4HQ, Cardiff, Wales, United Kingdom.
Anthony A GraceDepartments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Gating of Information Flow Within the Nucleus Accumbens (Supplement)R01MH057440 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANTHONY A GRACE · 1997 to 2026
$7.2M
NIMH NIH HHS R01 MH057440
6 · The paper itself

Abstract

Dysfunction in the GABAergic system has been described in schizophrenia, including decreased expression of α5 subunit-containing GABA

Indexed as

DopamineDopaminergic NeuronsReceptors, GABA-ASchizophreniaVentral Tegmental AreaAllosteric RegulationAnimalsDisease Models, AnimalDose-Response Relationship, DrugFemaleMaleMethylazoxymethanol AcetatePregnancyPrenatal Exposure Delayed EffectsRatsRats, Sprague-DawleyDopamineGabra5 protein, ratMethylazoxymethanol AcetateReceptors, GABA-ADopaminePositive allosteric modulatorsSchizophreniaα5-GABAAR

Identifiers

PMID41707438
PMCPMC13277557

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.