Evidence map›Paper›PMID 41707646›Full record

Trial reportCell reports. Medicine2026

A conserved eIF1A

Yifei Cheng, Lilin Wan, Enyao Huang, Bing Zheng, Xuefei Ding, Song Tan, Gaoxiang Ma, Wenchao Li, Chunyan Chu, Tiange Wu and 9 more

Abstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yifei ChengDepartment of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Lilin WanDepartment of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China. Electronic address: wanlilin2021@163.com.
Enyao HuangDepartment of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Bing ZhengDepartment of Urology, Affiliated Hospital 2 of Nantong University, Nantong 226001, China.
Xuefei DingDepartment of Urology, Northern Jiangsu People's Hospital, Yangzhou 225000, China.
Song TanDepartment of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Gaoxiang MaClinical Metabolomics Center, China Pharmaceutical University, Nanjing 211198, China.
Wenchao LiDepartment of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Chunyan ChuDepartment of Pathology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Tiange WuDepartment of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Shengrong ChenDepartment of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Junyong ZhuangDepartment of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Rong NaDepartment of Surgery, LKS School of Medicine, The University of Hong Kong, Hong Kong 999077, China.
Zhan ChenDepartment of Urology, Affiliated Hospital 2 of Nantong University, Nantong 226001, China.
Gaojun TengCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China; Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University), State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing 210009, China.
Dingxiao ZhangSchool of Biomedical Sciences, Hunan University, Changsha 410082, China. Electronic address: zdx1980@hnu.edu.cn.
Shenghong JuNurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China. Electronic address: jsh@seu.edu.cn.
Ming ChenDepartment of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China. Electronic address: mingchen0712@seu.edu.cn.
Bin XuDepartment of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China; National Medicine-Engineering Interdisciplinary Industry-Education Integration Innovation Platform (Ministry of Education), Basic Medicine Research and Innovation Center, Southeast University, Nanjing 210009, China. Electronic address: njxbseu@seu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PCa) is a malignancy with high heterogeneity arising from tumor microenvironment and histological subtypes. Identifying conserved progression drivers within such heterogeneity is essential for improving clinical outcomes. Using imaging mass cytometry, this study analyzes 38 proteins across paracancerous tissue and four histological subtypes: low-grade prostate acinar adenocarcinoma (LgPAC), high-grade PAC (HgPAC), intraductal carcinoma (IDC), and ductal adenocarcinoma (DAC). Results reveal that eIF1A is overexpressed in high-risk subtypes including HgPAC, IDC, and DAC and correlates with poor prognosis. In luminal cells, EIF1A knockdown and the translation inhibitor homoharringtonine (HHT) both suppress HIF-1α translation and tumor growth, while promoting infiltration of anticancer immune cells including PD-1

Indexed as

Hypoxia-Inducible Factor 1, alpha SubunitProstatic NeoplasmsTumor MicroenvironmentCell Line, TumorDisease ProgressionGene Expression Regulation, NeoplasticHumansMaleHypoxia-Inducible Factor 1, alpha Subunitductal adenocarcinomaeIF1Ahomoharringtoninehypoxiaimaging mass cytometryintraductal carcinomaprostate cancertranslationtumor microenvironment

Identifiers

PMID41707646
PMCPMC12923978

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.