Evidence map›Paper›PMID 41707749›Full record

ArticleCellular and molecular gastroenterology and hepatology2026

Tryptophan Indole Metabolites Reduce Anastomotic Leakage Through Aryl Hydrocarbon Receptor-Driven Interleukin-22 Production.

Vasiliki Bantavi, Laura Gloeck, Patrick Leven, Konstantina Zafeiropoulou, Olaf Welting, Hilal Sengül, Patrik Efferz, Bianca Schneiker, Timothy Ryan McCulloch, Christoph Wilhelm and 7 more

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Article in Cellular and molecular gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Vasiliki BantaviDepartment of General, Visceral, Thoracic, and Vascular Surgery, University Hospital Bonn, University of Bonn, Bonn, Germany; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Laura GloeckDepartment of General, Visceral, Thoracic, and Vascular Surgery, University Hospital Bonn, University of Bonn, Bonn, Germany.
Patrick LevenDepartment of General, Visceral, Thoracic, and Vascular Surgery, University Hospital Bonn, University of Bonn, Bonn, Germany.
Konstantina ZafeiropoulouTytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands; Department of Pediatric Surgery, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Olaf WeltingTytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Hilal SengülDepartment of General, Visceral, Thoracic, and Vascular Surgery, University Hospital Bonn, University of Bonn, Bonn, Germany; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Patrik EfferzDepartment of General, Visceral, Thoracic, and Vascular Surgery, University Hospital Bonn, University of Bonn, Bonn, Germany.
Bianca SchneikerDepartment of General, Visceral, Thoracic, and Vascular Surgery, University Hospital Bonn, University of Bonn, Bonn, Germany.
Timothy Ryan McCullochImmunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Christoph WilhelmImmunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Sandra BlaessNeurodevelopmental Genetics, Medical Faculty, Institute of Reconstructive Neurobiology, University of Bonn, Bonn, Germany.
Anneke FussNeurodevelopmental Genetics, Medical Faculty, Institute of Reconstructive Neurobiology, University of Bonn, Bonn, Germany.
REVEAL study group
Joep P M DerikxDepartment of Pediatric Surgery, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Bruno SovranTytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands; Department of Pediatric Surgery, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands; Emma Center for Personalized Medicine, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, The Netherlands.
Wouter J de JongeDepartment of General, Visceral, Thoracic, and Vascular Surgery, University Hospital Bonn, University of Bonn, Bonn, Germany; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Sven WehnerDepartment of General, Visceral, Thoracic, and Vascular Surgery, University Hospital Bonn, University of Bonn, Bonn, Germany. Electronic address: sven.wehner@ukbonn.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsColorectal cancer (CRC) often requires surgical resection of the tumor and an anastomosis. Anastomotic leakage (AL) occurs in 2.8% to 30% of patients, which increases postoperative morbidity and complications. The preoperative microbiome composition is implicated in AL. Recent studies have shown that microbial tryptophan (Trp) metabolism into aryl hydrocarbon receptor (AhR) indole-derivatives contributes to intestinal tissue healing. Here, we addressed the role of Trp and its metabolites in AL in a CRC patient cohort and a colon-anastomosis mouse model.

methodsTargeted quantitative metabolomics was performed in preoperative fecal samples from patients with CRC recruited in the REVEAL cohort (n = 388), including 19 AL cases. Anastomotic healing (AH) was tested in a mouse model using wild-type (WT), AhR

resultsFifty-two of the 388 patients with available preoperative fecal samples were matched for AH/AL occurrence (AL, n = 19; AH, n = 33). Among Trp metabolites, indole-3-acetic acid was significantly reduced in AL compared with matched AH male patients. AhR

conclusionsStimulation of the AhR/IL-22 by synthetic agonists or dietary-derived Trp-metabolites can prevent AL.

Indexed as

Anastomotic LeakBasic Helix-Loop-Helix ProteinsColorectal NeoplasmsIndolesInterleukinsReceptors, Aryl HydrocarbonTryptophanAgedAnastomosis, SurgicalAnimalsColonDisease Models, AnimalFecesFemaleHumansIndoleacetic AcidsBasic Helix-Loop-Helix Proteinsindoleacetic acidIndoleacetic AcidsIndolesInterleukin-22InterleukinsReceptors, Aryl HydrocarbonTryptophanAryl Hydrocarbon ReceptorInterleukin-22Intestinal Anastomotic LeakageTryptophan Metabolism

Identifiers

PMID41707749
PMCPMC13094658

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.