Evidence map›Paper›PMID 41707866›Full record

ArticleDevelopmental biology2026

In vitro plasticity between ureteric epithelial and distal nephron identity and maturity is controlled by extracellular signals.

Pamela Kairath, Pei Xuan Er, Sean Wilson, Irene Ghobrial, Jessica M Vanslambrouck, Yi-Hsien Chen, Shondra M Pruett-Miller, Sanjay Jain, Melissa H Little

Abstract read
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In one paragraph

Article in Developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Update of
    2025
5 · Who and what money

Authors and funding

9 authors.

Pamela KairathMurdoch Children's Research Institute, Parkville, Melbourne, 3052, Australia.
Pei Xuan ErMurdoch Children's Research Institute, Parkville, Melbourne, 3052, Australia.
Sean WilsonMurdoch Children's Research Institute, Parkville, Melbourne, 3052, Australia.
Irene GhobrialMurdoch Children's Research Institute, Parkville, Melbourne, 3052, Australia.
Jessica M VanslambrouckMurdoch Children's Research Institute, Parkville, Melbourne, 3052, Australia.
Yi-Hsien ChenWashington University Medical School, St. Louis, USA.
Shondra M Pruett-MillerWashington University Medical School, St. Louis, USA; St. Jude Children's Research Hospital, Memphis, TN, USA.
Sanjay JainWashington University Medical School, St. Louis, USA.
Melissa H LittleMurdoch Children's Research Institute, Parkville, Melbourne, 3052, Australia; Department of Pediatrics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, 3052, Australia; Department of Anatomy and Neuroscience, The University of Melbourne, VIC, Australia; Novo Nordisk Foundation Centre for Stem Cell Medicine, University of Copenhagen, Denmark. Electronic address: melissa.little@mcri.edu.au.

Funding

Research Project 2: Molecular analysis of developing post-natal mouse kidney in health and FSGSP50DK133943 · WASHINGTON UNIVERSITY · 2025 to 2025
$795k
NIDDK NIH HHS P50 DK133943NIDDK NIH HHS UH2 DK107344
6 · The paper itself

Abstract

Several studies have described human pluripotent stem cell (hPSC)-derived ureteric epithelium, which in the embryo arises from the nephric duct and forms the collecting ducts of the kidney. However, hPSC-derived distal nephron epithelium can also adopt a ureteric phenotype, despite this apparently not occurring during embryogenesis. In this study, RET

Indexed as

NephronsUreterAnimalsCell DifferentiationCoculture TechniquesEpithelial CellsEpitheliumHumansMicePluripotent Stem CellsR-SpondinsThrombospondinsR-SpondinsThrombospondinsDistal tubuleKidney organoidNephric ductPlasticityPluripotent stem cell

Identifiers

PMID41707866
PMCPMC13038311

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.