ArticleHuman brain mapping2026
The Relationship Between Hippocampal Cerebrovascular Reactivity and Brain Structure in Older Age.
Congxiyu Wang, Lucy Jobbins, Graham Reid, Georgina Hobden, Raihaan Patel, Clare E Mackay, Klaus P Ebmeier, Joana Pinto, Daniel Bulte, Mika Kivimäki and 2 more
Abstract read
In one paragraphArticle in Human brain mapping, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Lucy JobbinsNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Graham ReidDepartment of Experimental Psychology, University of Oxford, Oxford, UK.
Georgina HobdenDepartment of Experimental Psychology, University of Oxford, Oxford, UK.
Raihaan PatelDepartment of Psychiatry, University of Oxford, Oxford, UK.
Clare E MackayDepartment of Psychiatry, University of Oxford, Oxford, UK.
Joana PintoInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.
Daniel BulteInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.
Mika KivimäkiUCL Brain Sciences, University College London, London, UK.
Archana Singh-ManouxUCL Brain Sciences, University College London, London, UK.
Sana SuriDepartment of Psychiatry, University of Oxford, Oxford, UK.
Funding
Education, socioeconomic status and Aging: transitions from multimorbidity to functional limitations and mortalityR01AG056477 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2018 to 2022
$2.8MRole of mid- and late-life risk factors in social inequalities in Alzheimer's Disease and Related DementiasRF1AG062553 · NIA · INSERM PARIS 5 · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2019 to 2019
$1.5MBritish Heart Foundation RG/13/2/30098Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts (Lifebrain) EUHorizon2020ProgrammeGrantagreementID732592National Institute on Aging (NIA), National Institutes of Health (NIH), United States R01AG056477National Institute on Aging (NIA), National Institutes of Health (NIH), United States RF1AG062553NIHR Oxford Health Biomedical Research Centre NIHR203316The Academy of Medical Sciences/the Wellcome Trust/the Government Department of Business, Energy and Industrial Strategy/the British Heart Foundation/Diabetes UK Springboard Award SBF006\1078The HDH Wills 1965 Charitable TrustUK Alzheimer's Society 441UK Medical Research Council G1001354/1UK Medical Research Council MR/K013351/1UK Medical Research Council R024227UK Medical Research Council S011676University of Oxford HMD00740.HQ02.01Wellcome Trust 203139/A/16/ZWellcome Trust 203139/Z/16/ZWellcome Trust 221854/Z/20/Z
6 · The paper itselfAbstract
Cerebral autoregulatory mechanisms such as cerebrovascular reactivity (CVR) are impaired in dementia. However, their associations with brain structure, especially in the hippocampus, remain unclear. We investigated associations between hippocampal CVR and hippocampal volume, white matter microstructural integrity, and white matter hyperintensities in older adults. 163 participants from the Heart and Brain Study received multimodal MRI scans, including T1-weighted structural imaging, diffusion tensor imaging, fluid-attenuated inversion recovery imaging at Wave 1 (2012-2014, mean age 68.2, SD 4.4 years) and Wave 2 (2019-2023, mean age 76.9, SD 4.5 years). Participants also received BOLD fMRI scans with a 5% CO
Indexed as
AgingCerebrovascular CirculationHippocampusWhite MatterAgedAged, 80 and overCross-Sectional StudiesDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleageing braincerebrovascular reactivitygrey matter volumehippocampuswhite matter microstructure
Identifiers
PMID41708486
PMCPMC12916246
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