Articlenpj aging2026
Molecular insight into transcriptome profiling of aerobic exercise induced changes in aged skeletal muscle.
Article in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle aging causes loss of both muscle mss and strength, often leading to sarcopenia. Clinical manifestation of sarcopenia has been found to improve with exercise intervention. The molecular mechanisms in response to exercise intervention in aged skeletal muscles are not fully understood. We performed transcriptomic profiling of aged animal model with exercise intervention for identifying the plausible mechanism leading to enhanced muscle function. Expression levels of 43,629 RNAs were analyzed for the process of aging and exercise intervention. Differentially expressed genes showed 22,196 protein-coding and 21,433 non-coding RNAs that were found to be significantly altered with intervention. Genes associated with extracellular matrix and inflammatory responses exhibited significant change with intervention. Slpi (Secretory Leukocyte Protease Inhibitor)- a vital gene in the intervention group with its role as an inflammatory regulator and tissue repair gene. The activation of quisqualate receptor, neurotransmitter receptors and postsynaptic signal transmission pathways were most relevant for upregulated genes in the intervention group. Downregulated genes in the intervention group were mostly associated with ATP-dependent protein disaggregase activity. Our study provides a comprehensive analysis of the global transcriptome that governs aerobic exercise induced changes in aged muscle leading to compensatory adaptation with exercise in aged model group.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.