Evidence map›Paper›PMID 41708672›Full record

ArticleScientific reports2026

Inositol hexakisphosphate kinase 1 is implicated in the insulin response to protein ingestion in older adults.

Richie D Barclay, Diana E Motei, Oana Ancu, Christopher J Tyler, Neale A Tillin, Volker Behrends, Nicholas A Burd, Nicholas M Hurren, Richard W A Mackenzie

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Richie D BarclaySchool of Life and Health Sciences, University of Roehampton, London, UK.
Diana E MoteiSchool of Life and Health Sciences, University of Roehampton, London, UK.
Oana AncuSchool of Life and Health Sciences, University of Roehampton, London, UK.
Christopher J TylerSchool of Life and Health Sciences, University of Roehampton, London, UK.
Neale A TillinSchool of Life and Health Sciences, University of Roehampton, London, UK.
Volker BehrendsSchool of Biomedical Science, University of West London, London, UK.
Nicholas A BurdDivision of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Nicholas M HurrenSchool of Life and Health Sciences, University of Roehampton, London, UK.
Richard W A MackenzieSchool of Life and Health Sciences, University of Roehampton, London, UK. ae2719@coventry.ac.uk.ORCID https://orcid.org/0000-0001-6799-6218

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related muscle mass is driven by a reduction in insulin sensitivity partly mediated by reduced amino acid and anabolic signalling kinetics. Insulin activates Akt-mTORC1 signalling in skeletal muscle, with inositol hexakisphosphate kinase 1 (IP6K1) shown to inhibit this signalling pathway in pre-diabetic humans. We aimed to compare muscle and plasma IP6K1 in young vs older adults and the possible role of IP6K1 in the anabolic response to protein and protein plus resistance exercise (RE). Nine young (24.9 ± 0.4 years) and nine older (66.2 ± 0.5 years), moderately active adults received primed continuous infusions of L-[ring-

Indexed as

InsulinPhosphotransferases (Phosphate Group Acceptor)AdultAgedExerciseFemaleHumansInsulin ResistanceMaleMuscle, SkeletalPhenylalaninePostprandial PeriodSignal TransductionYoung AdultInsulinIP6K1 protein, humanPhenylalaninePhosphotransferases (Phosphate Group Acceptor)AgeingAmino acidsInsulin resistanceIP6K1MetabolismResistance exercise

Identifiers

PMID41708672
PMCPMC13005028

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.