Evidence map›Paper›PMID 41708705›Full record

ArticleScientific reports2026

Environmental co-exposure to organophosphate and pyrethroid pesticides and mental health status in rural communities near an industrial pig farming facility.

Rocío Hojas, José Norambuena, América Ponce, Joaquín Toro, Jandy Adonis-Rojas, Sebastián Pozo, Bárbara Figueroa, Francisca Cabezas, Cristian Valdés, Liliana Zúñiga-Venegas and 13 more

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Rocío HojasSchool of Medicine, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, Chile.
José NorambuenaSchool of Medicine, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, Chile.
América PonceSchool of Medicine, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, Chile.
Joaquín ToroSchool of Medicine, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, Chile.
Jandy Adonis-RojasMaster in Public Health, School of Public Health, Faculty of Medicine, Universidad de Chile, Independencia 939, Santiago, Chile.
Sebastián PozoMedical Specialty in Public Health, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, Chile.
Bárbara FigueroaSchool of Biotechnology Engineering, Faculty of Agricultural and Forestry Sciences, Universidad Católica del Maule, Avenida San Miguel 3605, Talca, Chile.
Francisca CabezasDepartment of Agricultural Production, Faculty of Agricultural Sciences, Universidad de Chile, Avenida Santa Rosa 11315, La Pintana, Santiago, Chile.
Cristian ValdésSchool of Biotechnology Engineering, Faculty of Agricultural and Forestry Sciences, Universidad Católica del Maule, Avenida San Miguel 3605, Talca, Chile.
Liliana Zúñiga-VenegasCentro de Investigación de Estudios Avanzados del Maule (CIEAM) , Universidad Católica del Maule, Avenida San Miguel 3605, Talca, Chile.
Benjamín CastilloCentro de Investigación de Estudios Avanzados del Maule (CIEAM) , Universidad Católica del Maule, Avenida San Miguel 3605, Talca, Chile.
Natalia LanderosFacultad de Medicina, Universidad Católica del Maule, Avenida San Miguel 3605, Talca, Chile.
Boris LuceroResearch Center in Neuropsychology and Cognitive Neurosciences (CINPSI Neurocog), Faculty of Health Sciences, Universidad Católica del Maule, Avenida San Miguel 3605, Talca, Chile.
Ramón D CastilloCentro de Investigación en Ciencias Cognitivas, Facultad de Psicología, Universidad de Talca, Avenida Lircay s/n, Talca, Chile.
Cynthia CarrascoResearch Center in Neuropsychology and Cognitive Neurosciences (CINPSI Neurocog), Faculty of Health Sciences, Universidad Católica del Maule, Avenida San Miguel 3605, Talca, Chile.
Juan Pablo Gutiérrez-JaraCentro de Investigación de Estudios Avanzados del Maule (CIEAM) , Universidad Católica del Maule, Avenida San Miguel 3605, Talca, Chile.
Catalina SaavedraCentro de Investigación en Ciencias Cognitivas, Facultad de Psicología, Universidad de Talca, Avenida Lircay s/n, Talca, Chile.
Patricio YáñezCentro de Investigación en Ciencias Cognitivas, Facultad de Psicología, Universidad de Talca, Avenida Lircay s/n, Talca, Chile.
María Ignacia ValdésResearch Center in Neuropsychology and Cognitive Neurosciences (CINPSI Neurocog), Faculty of Health Sciences, Universidad Católica del Maule, Avenida San Miguel 3605, Talca, Chile.
María Victoria RodríguezResearch Center in Neuropsychology and Cognitive Neurosciences (CINPSI Neurocog), Faculty of Health Sciences, Universidad Católica del Maule, Avenida San Miguel 3605, Talca, Chile.
Andrés Canales-JohnsonResearch Center in Neuropsychology and Cognitive Neurosciences (CINPSI Neurocog), Faculty of Health Sciences, Universidad Católica del Maule, Avenida San Miguel 3605, Talca, Chile.
Tristan BekinschteinConsciousness and Cognition Lab, Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
María Teresa Muñoz-QuezadaSchool of Public Health, Faculty of Medicine, Universidad de Chile, Independencia 939, Santiago, Chile. mtmunoz@uchile.cl.

Funding

Fondo Nacional de Desarrollo Científico y Tecnológico , Chile FONDECYT 1240899
6 · The paper itself

Abstract

Chronic exposure to pesticide residues from large-scale agro-livestock operations remains insufficiently characterized, particularly among rural populations living near industrial pig farming facilities. This study examined the association between co-exposure to organophosphate and pyrethroid pesticide residues in soil and well water and mental health outcomes among adults residing near an industrial pig farming facility in rural Chile. A cross-sectional study was conducted with 82 adults. Peridomestic soil and well water samples were analyzed using gas chromatography–tandem mass spectrometry to detect five pesticides: chlorpyrifos, diazinon, pirimiphos-methyl, cypermethrin, and lambda-cyhalothrin. Mental health outcomes included depressive symptoms, anxiety, emotional affect, and health-related quality of life, assessed with validated instruments. Robust linear regression models were used, adjusting for age, sex, education level, and body mass index. Higher chlorpyrifos concentrations in water were associated with increased depressive symptom scores (β = 0.180; 95% CI: 0.016, 0.345) and lower mental health-related quality of life (β = −0.713; 95% CI: −1.288, − 0.137). Cypermethrin concentrations in water were associated with higher psychological distress (β = 0.324; 95% CI: 0.124, 0.525). In soil, pirimiphos-methyl was positively associated with depressive symptoms (β = 21.29; 95% CI: 1.78, 40.79), whereas cypermethrin showed an inverse association (β = −3.66; 95% CI: −6.99, − 0.33). Lambda-cyhalothrin concentrations in soil were inversely associated with overall quality of life (β = −15.13; 95% CI: −27.42, − 2.84). Male sex was positively associated with overall quality of life (β = 14.96; 95% CI: 3.14, 26.79). These findings indicate associations between environmental pesticide residues in soil and water and multiple dimensions of mental health among rural populations living near industrial pig farming operations. Longitudinal studies are needed to clarify temporal relationships and potential cumulative effects.

Indexed as

Environmental ExposureMental HealthOrganophosphatesPesticidesPyrethrinsAdultAnimalsCross-Sectional StudiesDepressionFemaleHumansMaleMiddle AgedQuality of LifeRural PopulationSwineOrganophosphatesPesticidesPyrethrinsAnxietyDepressionEnvironmental exposureMental healthPesticides

Identifiers

PMID41708705
PMCPMC13013602

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.