Evidence map›Paper›PMID 41708848›Full record

ArticleNature2026

Ancient co-option of LTR retrotransposons as yeast centromeres.

Max A B Haase, Luciana Lazar-Stefanita, Lyam Baudry, Aleksandra Wudzinska, Xiaofan Zhou, Antonis Rokas, Chris Todd Hittinger, Boris Pfander, Andrea Musacchio, Jef D Boeke

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. A Translocation within thebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Discovery of additional ancient genome duplications in yeasts.bioRxiv : the preprint server for biology · 2025
    Article
  7. Centromeres in the thermotolerant yeast K. marxianus mediate attachment to a single microtubule.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Max A B HaaseDepartment of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany. max.haase@mpi-dortmund.mpg.de.ORCID 0000-0002-8962-0446
Luciana Lazar-StefanitaInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.ORCID 0000-0003-2388-9757
Lyam BaudryCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-9283-674X
Aleksandra WudzinskaInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Xiaofan ZhouGuangdong Provincial Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Center, South China Agricultural University, Guangzhou, China.ORCID 0000-0002-2879-6317
Antonis RokasDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-7248-6551
Chris Todd HittingerLaboratory of Genetics, Center for Genomic Science Innovation, J. F. Crow Institute for the Study of Evolution, DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-5088-7461
Boris PfanderCell Biology, Dortmund Life Science Center (DOLCE), Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Andrea MusacchioDepartment of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.ORCID 0000-0003-2362-8784
Jef D BoekeInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA. Jef.Boeke@nyulangone.org.ORCID 0000-0001-5322-4946

Funding

Somatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI John M Sedivy · 2016 to 2026
$30.4M
Deciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relativesR01AI153356 · NIAID · VANDERBILT UNIVERSITY · PI Antonis Rokas · 2022 to 2026
$3.5M
NIAID NIH HHS R01 AI153356NIA NIH HHS P01 AG051449
6 · The paper itself

Abstract

Centromeres ensure accurate chromosome segregation, yet their DNA evolves rapidly across eukaryotes leaving the origins of new centromere architectures unclear

Indexed as

CentromereEvolution, MolecularRetroelementsSaccharomyces cerevisiaeChromosomes, FungalEpigenesis, GeneticNucleosomesPhylogenyTerminal Repeat SequencesNucleosomesRetroelements

Identifiers

PMID41708848
PMCPMC13017519

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.