Evidence map›Paper›PMID 41708863›Full record

ArticleNature2026

RYK is a GPNMB receptor that drives MASH.

Yue Xi, Waner Zeng, Jie Luo, Jian Zhou, Lin Wang, Jingyi Sun, Zengyiting He, Weihui Li, Sitao Zhu, Wei Qi and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yue XiState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences, Wuhan University, Wuhan, China.ORCID 0000-0003-1265-6624
Waner ZengState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences, Wuhan University, Wuhan, China.ORCID 0000-0001-9528-3661
Jie LuoState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences, Wuhan University, Wuhan, China.ORCID 0009-0006-8176-7036
Jian ZhouNovo Nordisk Research Centre China, Novo Nordisk A/S, Beijing, China.
Lin WangNovo Nordisk Research Centre China, Novo Nordisk A/S, Beijing, China.
Jingyi SunState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences, Wuhan University, Wuhan, China.ORCID 0009-0004-9961-8763
Zengyiting HeState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences, Wuhan University, Wuhan, China.ORCID 0009-0009-7058-835X
Weihui LiState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences, Wuhan University, Wuhan, China.ORCID 0000-0003-3122-3453
Sitao ZhuState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences, Wuhan University, Wuhan, China.ORCID 0000-0002-1978-8323
Wei QiSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China. qiwei@shanghaitech.edu.cn.ORCID 0000-0003-0813-5316
Bao-Liang SongState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences, Wuhan University, Wuhan, China. blsong@whu.edu.cn.ORCID 0000-0002-6397-5935

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of metabolic-dysfunction-associated steatohepatitis (MASH) is rising globally, yet effective treatments remain limited

Indexed as

Fatty LiverMembrane GlycoproteinsAnimalsDisease ProgressionEye ProteinsFemaleGPI-Linked ProteinsHepatocytesHumansLipogenesisLiverMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLPPAR gammaEye ProteinsGPI-Linked ProteinsGPNMB protein, humanGpnmb protein, mouseMembrane GlycoproteinsPPAR gamma

Identifiers

PMID41708863

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.