ArticleNature2026
The integrated stress response promotes immune evasion through lipocalin 2.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Artificial intelligence-guided analysis of the tumor microenvironment predicts response to pembrolizumab in rare tumors.Journal for immunotherapy of cancer · 2026Trial
- Stress-induced lipocalin 2 remodels the tumor microenvironment to exclude T cells.Molecular biomedicine · 2026Article
- Anti-LCN2 antibody treatment is associated with attenuated hearing loss and blood-labyrinth barrier disruption in a mouse model of chronic kidney disease.Journal of molecular histology · 2026Article
- ATF4 orchestrates cancer hallmarks: Stress adaptation, metabolic reprogramming and immune suppression.iScience · 2026Review
- Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution.Nature cell biology · 2026Article
- ATF4 promotes immune evasion in oral squamous cell carcinoma by suppressing autophagic PD-L1 degradation.Journal for immunotherapy of cancer · 2026Article
- Artificial intelligence-powered H&E-based quantification of spatial tumor-infiltrating lymphocyte distribution identifies prognostic immune niches in colorectal cancer.Cancer immunology, immunotherapy : CII · 2026Article
- Stress Biology in Cancer: Neuroendocrine-Immune Mechanisms Linking Tumor Progression to Translational Interventions.Cancer communications (London, England) · 2026Review
- Extracellular Metabolites and Natural Killer Cell Antitumor Function: Mechanisms and Therapeutic Strategies.Research (Washington, D.C.) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors.
Jozef P Bossowski *Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2101-2863
Ray Pillai *Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8335-3463
John KilianLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
Angela Wong LauDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0009-0000-4685-3314
Mari NakamuraDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Ali RashidfarrokhiDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Yuan HaoDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Ruxuan LiDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Katherine WuDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0472-0166
Takamitsu HattoriLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.ORCID http://orcid.org/0000-0002-5502-2595
Eliezra GlasserLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.ORCID http://orcid.org/0000-0002-1371-4980
Akiko KoideLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.ORCID http://orcid.org/0000-0003-1796-7077
Lidong WangDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Andre L MoreiraDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Cristina HajduDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Sahith RajalingamDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Sarah E LeBoeufDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Hortense LeDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Seungeun LeeLunit, Seoul, Republic of Korea.ORCID http://orcid.org/0009-0007-6791-8296
Jin Woo OhLunit, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-3545-5481
Cheolyong JoeDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Hyemin KimDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Chan-Young OckLunit, Seoul, Republic of Korea.
Se-Hoon LeeDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-9219-3350
Hao WangDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Angana A H PatelSahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden.
Volkan I SayinSahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-5225-8260
Aristotelis TsirigosDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-7512-8477
Kwok-Kin WongDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-6323-235X
Sergei B KoralovDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-4843-3791
Mario PendeInstitut Necker Enfants Malades (INEM), Université Paris Cité, CNRS, Inserm, Paris, France.ORCID http://orcid.org/0000-0002-7864-8937
Francisco J Sánchez-RiveraDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8466-8563
Diane M SimeoneMoores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
Ioannis K ZervantonakisDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-2386-9553
Shohei KoideLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA. Shohei.Koide@nyulangone.org.ORCID http://orcid.org/0000-0001-5473-4358
Thales PapagiannakopoulosDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA. Thales.Papagiannakopoulos@nyulangone.org.ORCID http://orcid.org/0000-0002-2251-1624
Funding
Targeting LCN2, a novel therapy for lung cancerR01CA297605 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOHEI KOIDE, Thales Papagiannakopoulos · 2025 to 2026
$1.4MNCI NIH HHS R01 CA297605
Abstract
Cancer cells activate the integrated stress response (ISR) to adapt to stress and resist therapy
Indexed as
Immune EvasionLipocalin-2Stress, PhysiologicalTumor EscapeActivating Transcription Factor 4AdenocarcinomaAnimalsCell Line, TumorDisease Models, AnimalDisease ProgressionFemaleHumansLung NeoplasmsMacrophagesMaleMiceActivating Transcription Factor 4ATF4 protein, humanAtf4 protein, mouseLCN2 protein, humanLcn2 protein, mouseLipocalin-2
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.