Evidence map›Paper›PMID 41708866›Full record

ArticleNature2026

Nucleotide signals coordinate activation and inhibition of bacterial immunity.

Sonomi Yamaguchi, Samantha G Fernandez, Douglas R Wassarman, Marlen Lüders, Frank Schwede, Philip J Kranzusch

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Sonomi YamaguchiDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5562-8044
Samantha G FernandezDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Douglas R WassarmanDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6922-9378
Marlen LüdersBiolog Life Science Institute, Bremen, Germany.
Frank SchwedeBiolog Life Science Institute, Bremen, Germany.ORCID http://orcid.org/0000-0002-8185-3392
Philip J KranzuschDepartment of Microbiology, Harvard Medical School, Boston, MA, USA. philip_kranzusch@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-4943-733X

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
Discovery of cGAS-like signaling enzymes in innate immunity and diseaseDP2GM146250 · NIGMS · DANA-FARBER CANCER INST · PI KRANZUSCH, PHILIP J · 2021 to 2024
$2.5M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
NIGMS NIH HHS DP2 GM146250NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM133893NIH HHS S10 OD021527
6 · The paper itself

Abstract

The cellular nucleotide pool is a major focal point of the host immune response to viral infection. Immune effector proteins that disrupt the nucleotide pool enable animal and bacterial cells to broadly restrict diverse viruses, but reduced nucleotide availability induces cellular toxicity and can limit host fitness

Indexed as

Escherichia coliNucleotidesSignal TransductionThymine NucleotidesBacterial ProteinsBacteriophagesCryoelectron MicroscopyEscherichia coli ProteinsModels, MolecularBacterial ProteinsEscherichia coli ProteinsNucleotidesThymine Nucleotides

Identifiers

PMID41708866
PMCPMC13078526

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.