ArticleMolecular neurobiology2026
Macrophage-Derived Amphiregulin Enhances Schwann Cell Phagocytosis Through the EGFR/CTSS Signaling Pathway.
Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- CTSS regulates macrophage lipid metabolic reprogramming and white matter repair after intracerebral hemorrhage.Journal of translational medicine · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Schwann cells are non-professional phagocytes, their phagocytic function significantly contributes to myelin debris clearance, a critical process for Wallerian degeneration. However, whether their phagocytic capacity is modulated by professional phagocytes like macrophages remains unknown. This study demonstrates that following nerve injury, macrophages can secrete amphiregulin (AREG) to enhance the phagocytic capability of Schwann cells. Using an Areg conditional knockout (cKO) mouse model, we identified that macrophage-derived AREG activates the epidermal growth factor receptor (EGFR) on Schwann cells and upregulates Cathepsin S (CTSS) expression. CTSS restoration rescued the phagocytic defect in Schwann cells treated with conditioned medium from cKO. These findings reveal a novel paracrine mechanism wherein macrophages regulate Schwann cell phagocytosis via the AREG-EGFR-CTSS axis, highlighting a potential target for promoting myelin debris clearance and accelerating Wallerian degeneration after nerve injury.
Indexed as
Identifiers
41708964What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.