Evidence map›Paper›PMID 41709507›Full record

ArticlePharmaceutical biology2026

Phytochemical study of

Dyke Gita Wirasisya, Annamária Kincses, Arif Setiawansyah, Anita Barta, Fang-Rong Chang, Judit Hohmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dyke Gita WirasisyaInstitute of Pharmacognosy, University of Szeged, Faculty of Pharmacy, Szeged, Hungary.
Annamária KincsesInstitute of Pharmacognosy, University of Szeged, Faculty of Pharmacy, Szeged, Hungary.
Arif SetiawansyahAkademi Farmasi Cendikia Farma Husada, Bandar Lampung, Indonesia.
Anita BartaInstitute of Pharmacognosy, University of Szeged, Faculty of Pharmacy, Szeged, Hungary.
Fang-Rong ChangGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Judit HohmannInstitute of Pharmacognosy, University of Szeged, Faculty of Pharmacy, Szeged, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextColorectal cancer is the third most common and second deadliest cancer worldwide. Late diagnosis, poor outcomes in metastatic cases, and multidrug resistance emphasize the need for new therapies.

objectiveThis study aimed to isolate bioactive compounds from MATERIALS AND

methodsCompounds were isolated by chromatographic separations, and the structures were elucidated by NMR and HRESIMS. The antiproliferative activity was measured by MTT assay. DFT calculations were performed in ORCA 6.1.0. Network pharmacology was used to identify targets and pathways, molecular docking with AutoDock Vina was used to determine binding affinities, and pkCSM was applied to predict pharmacokinetics and toxicity.

results7β-Hydroxysitosterol ( DISCUSSION AND

conclusionsSix compounds were isolated from

Indexed as

Antineoplastic Agents, PhytogenicColorectal NeoplasmsDiterpenesPhytochemicalsPlant ExtractsAnimalsCell Line, TumorCell ProliferationGlycogen Synthase Kinase 3 betaHumansMolecular Docking SimulationNetwork PharmacologyAntineoplastic Agents, PhytogenicDiterpenesGlycogen Synthase Kinase 3 betaPhytochemicalsPlant Extractscolorectal cancerEuphorbiaceaeHomalanthus giganteusmolecular dockingnetwork pharmacologytigliane diterpenoids

Identifiers

PMID41709507
PMCPMC12922413

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.