Evidence map›Paper›PMID 41709576›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

Dual CD8 and TCR editing in regulatory T cells mediates HLA-A2-restricted tissue-specific homing.

Raphaël Porret, Fanny Lebreton, Eleonora Pace, Evangelos Stefanidis, Aikaterini Semilietof, Philippe Guillaume, Spiros Georgakis, Oscar Alfageme-Abello, Ana Alcaraz-Serna, Laura Ermellino and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. CD8 regulatory T cell therapy in transplantation: a new path to clinical success?Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Raphaël PorretDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland; Centre for Human Immunology Lausanne, 1005 Lausanne, Switzerland.
Fanny LebretonCell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, 1205 Geneva, Switzerland; Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, 1204 Geneva, Switzerland.
Eleonora PaceDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland.
Evangelos StefanidisLudwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Lausanne, Switzerland.
Aikaterini SemilietofLudwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Lausanne, Switzerland.
Philippe GuillaumeLudwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Lausanne, Switzerland.
Spiros GeorgakisDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland.
Oscar Alfageme-AbelloDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland.
Ana Alcaraz-SernaDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland.
Laura ErmellinoDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland.
Rebecca CecchinDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland.
Erica LanaDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland.
Morteza HafeziLudwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Lausanne, Switzerland.
Francesco ProcopioDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland.
Kevin BellofattoCell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, 1205 Geneva, Switzerland; Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, 1204 Geneva, Switzerland.
Greta Maria Paola Giordano AttianeseLudwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Lausanne, Switzerland.
Vincent ZoeteLudwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Lausanne, Switzerland.
Matthieu PerreauDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland; Centre for Human Immunology Lausanne, 1005 Lausanne, Switzerland.
Constantinos PetrovasDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland.
Melita IrvingLudwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Lausanne, Switzerland.
Ekaterine BerishviliCell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, 1205 Geneva, Switzerland; Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, 1204 Geneva, Switzerland.
Qizhi TangDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Yannick D MullerDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland; Centre for Human Immunology Lausanne, 1005 Lausanne, Switzerland. Electronic address: yannick.muller@chuv.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 diabetes (T1D) is marked by the overexpression of class I major histocompatibility complex (MHC) antigens in pancreatic islets, which are targeted by islet-specific CD8

Indexed as

CD8 AntigensCD8-Positive T-LymphocytesGene EditingHLA-A2 AntigenReceptors, Antigen, T-CellT-Lymphocytes, RegulatoryAnimalsCell MovementDiabetes Mellitus, Type 1HumansIslets of LangerhansMiceOrgan SpecificityCD8 AntigensHLA-A2 AntigenReceptors, Antigen, T-CellCD8 editingengineered TCRHLA-A2isletmigrationregulatory T celltoleranceTreg therapytype 1 diabetes

Identifiers

PMID41709576
PMCPMC13239781

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.