ArticleJournal of the Endocrine Society2026
Body composition changes after 6 and 12 months of dietary weight loss: insights from the DIETFITS trial.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01826591 (Do Insulin Secretion or Genotype Pattern Predict Low Fat vs Low Carb Weight Loss Success?), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Do Insulin Secretion or Genotype Pattern Predict Low Fat vs Low Carb Weight Loss Success?
Who cites it
1 citing paper in PubMed.
- Body composition changes after 6 and 12 months of dietary weight loss: insights from the DIETFITS trial.Journal of the Endocrine Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Context: While popular weight-loss medications have raised concerns about lean mass loss, the normative effects of nonpharmacologic weight loss on body composition remain unclear. Objective: We assessed how the extent of weight loss from dietary changes affects lean mass and bone mineral content (BMC) in women and men. Methods: We conducted a secondary analysis of the DIETFITS trial (NCT01826591), a randomized controlled study with 609 adults (aged 18-50, body mass index [BMI] 28-40). Data from 323 participants (200 women, 123 men) who lost weight at 6 months and had dual-energy x-ray absorptiometry (DXA) assessments at baseline, 6 months, and 12 months were analyzed. Participants were stratified as follows: less than 5% (n = 102), 5% to 9% (n = 121), and 10% or more (n = 100). The primary outcome was the percentage of lean mass lost relative to total weight loss (%LML). Results: Baseline mean BMI (33 kg/m Conclusion: Contrary to our hypothesis, %LML plateaus with greater weight loss. Moreover, men experience greater %LML than women. The decline in BMC despite weight regain warrants further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.