Evidence map›Paper›PMID 41710303›Full record

ArticleAnimal cells and systems2026

ATP release mediated by TRPM3 enhances invasion in glioblastoma.

Kkot Garam Bae, Chae Won Song, Jae Hong Yoo, Myunghoon Lee, Noah Koo, Gangsan Lee, Yongmin Mason Park, Jihwan Yoo, In-Young Hwang, Dong Ho Woo and 2 more

Abstract read
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In one paragraph

Article in Animal cells and systems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kkot Garam BaeDepartment of Biological Science, Chungnam National University, Daejeon, Republic of Korea.
Chae Won SongDepartment of Biological Science, Chungnam National University, Daejeon, Republic of Korea.
Jae Hong YooDepartment of Biological Science, Chungnam National University, Daejeon, Republic of Korea.
Myunghoon LeeDepartment of Biological Science, Chungnam National University, Daejeon, Republic of Korea.
Noah KooDepartment of Biological Science, Chungnam National University, Daejeon, Republic of Korea.
Gangsan LeeDepartment of Biological Science, Chungnam National University, Daejeon, Republic of Korea.
Yongmin Mason ParkGroup of Cognitive Glioscience, Center for Memory and Glioscience, Institute for Basic Science, Daejeon, Republic of Korea.
Jihwan YooDepartment of Neurosurgery, Brain Tumor Center, Gangnam Severance Hospital, Seoul, Republic of Korea.
In-Young HwangGroup of Cognitive Glioscience, Center for Memory and Glioscience, Institute for Basic Science, Daejeon, Republic of Korea.
Dong Ho WooCenter for Global Biopharmaceutical Research, Korea Institute of Toxicology, Daejeon, Republic of Korea.
C Justin LeeGroup of Cognitive Glioscience, Center for Memory and Glioscience, Institute for Basic Science, Daejeon, Republic of Korea.
Kyung-Seok HanDepartment of Biological Science, Chungnam National University, Daejeon, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is the most aggressive and lethal form of primary brain tumor, characterized by uncontrolled proliferation and invasion into surrounding brain tissue. Mechanical stimulation (MS) in the tumor microenvironment (TME) has been correlated to tumor progression, partly via ATP release. However, the underlying molecular mechanisms remain poorly understood. In this study, we found that transient receptor potential melastatin 3 (TRPM3) channel mediates MS-induced ATP release from GBM cells. Genetic knockdown of TRPM3 significantly attenuated ATP release and suppressed GBM cell invasion, indicating its functional relevance in tumor dissemination. Furthermore, TRPM3 regulated ATP release in a Ca

Indexed as

ATPGlioblastomainvasionmechanical stimulationTRPM3

Identifiers

PMID41710303
PMCPMC12912218

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.