ArticleFrontiers in cardiovascular medicine2026
Systemic immune-inflammation index, neutrophil to high-density lipoprotein ratio and pre-hospital delay: promising biomarkers for predicting the prognosis of patients with acute ST-elevation myocardial infarction.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Background: Research has confirmed the relationship between acute inflammation, lipid metabolism disorders, and the occurrence of coronary heart disease. However, no studies have analyzed the association between inflammation and lipid-related indicators with the poor prognosis of STEMI (ST-Elevation Myocardial Infarction) patients. Methods: The retrospective cohort study enrolled 556 patients diagnosed with STEMI. According to 18 Months follow-up outcomes, participants were categorized into either the MACE group or the non MACE group. Additionally, patients were stratified based on their systemic immune-inflammatory index (SII), neutrophil to high-density lipoprotein ratio (NHR), and pre-hospital delay time) levels using optimal cut-off points. The predictive value of SII, NHR and PHDT alone or combined was evaluated using receiver operating characteristic (ROC) curves. Risk factors of MACE in STEMI patients were detected by Multivariable Cox regression analysis. In addition, the Kaplan-Meier approach was applied to assess the long-term survival rates of different. levels of SII, NHR and PHDT in STEMI patient. Results: The levels of SII, NHR and PHDT were significantly higher in the MACE group as compared to the non-MACE group. The ROC curve analysis demonstrated that SII, NHR and PHDT possess considerable predictive power for the development of MACE in STEMI patients. Furthermore, the area under the curve of the combination of SII, NHR and PHDT was 0.819 (95% CI: 0.78-0.85, Conclusion: Elevated levels of SII, NHR and PHDT correlate closely with MACE in patients with STEMI, and demonstrate predictive value.
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