ReviewJournal of multidisciplinary healthcare2026
Strategies for Managing Fluids and Electrolytes in High-Output Stomas: A Systematic Review and Evidence Summary.
Review in Journal of multidisciplinary healthcare, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to explore intervention strategies for fluid and electrolyte regulation in patients with high-output stomas, to optimize their clinical outcomes and quality of life. Results: Fifteen experimental and semi-experimental studies were systematically reviewed. Interventions were categorized into five types by therapeutic purpose and route: gastrointestinal motility/anti-secretory agents, Glucagon-like Peptide-1/2 (GLP-1/2) analogs, rehydration/electrolyte supplements, micronutrient supplements, and dietary restriction. Key HOS complications included hyponatremia, hypomagnesemia, metabolic acidosis, hypokalemia, hypocalcemia, and kidney injury. Conclusion: Hydro-electrolyte management in patients with HOS requires a multidisciplinary approach that integrates fluid management, pharmacotherapy, nutritional support, and surgical intervention. This framework may reduce dehydration-related readmission and improve outcomes. Future large-scale prospective studies are warranted to verify the efficacy, safety, and novel therapies, explore new therapeutic targets/drugs, and develop standardized guidelines, with an emphasis on individualized management for complex cases and prioritizing patient quality of life.
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