Trial reportFrontiers in pharmacology2026
A prospective feasibility study evaluating the implementation of model-informed precision dosing in critically ill children.
Trial report in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07315438 (Model-Informed Precision Dosing on Amikacin and Vancomycin Therapy in Critically Ill Children), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Model-Informed Precision Dosing on Amikacin and Vancomycin Therapy in Critically Ill Children: A Pilot Randomized Clinical Trial
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Achieving optimal antibiotic exposure in critically ill pediatric patients is difficult due to (their) dynamic physiology and variability. Conventional weight-based regimens often fail to reach pharmacokinetic/pharmacodynamic (PK/PD) targets for narrow therapeutic index agents such as vancomycin and amikacin. Model-Informed Precision Dosing (MIPD), which integrates Bayesian forecasting with population pharmacokinetics (popPK), offers a potentially valuable yet underexplored approach in pediatric intensive care to better attain and sustain target exposure. This study was designed as a prospective, pragmatic feasibility study with a comparator arm, employing observational analyses to evaluate the implementation and methodological performance of MIPD in a tertiary pediatric intensive care unit. Pediatric patients receiving vancomycin or amikacin were managed either with MIPD-guided dosing using a clinical decision support platform or with standard-of-care (SoC) dosing. Primary outcomes included prediction accuracy ( Clinical Trial Registration: ClinicalTrials.gov, identifier NCT07315438.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.