Evidence map›Paper›PMID 41710979›Full record

ArticleJournal of medicinal chemistry2026

Structure-Activity Relationship Studies toward the Optimization of First-In-Class Selective Small Molecule Agonists of the GPCR Relaxin/Insulin-like Family Peptide Receptor 2.

Kenneth J Wilson, Maria Esteban-Lopez, Courtney Myhr, Wenjuan Ye, Curtis E Moore, Noel Southall, Xin Hu, Abhijeet Kapoor, Konstantinos Afratis, Christopher A LeClair and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Kenneth J WilsonNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Maria Esteban-LopezDepartment of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 11200 SW Eighth Street, HLSI 419B, Miami, Florida 33199, United States.
Courtney MyhrDepartment of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 11200 SW Eighth Street, HLSI 419B, Miami, Florida 33199, United States.
Wenjuan YeNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Curtis E MooreDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-3311-7155
Noel SouthallNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.ORCID 0000-0003-4500-880X
Xin HuNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Abhijeet KapoorNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Konstantinos AfratisNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.ORCID 0000-0003-4068-6900
Christopher A LeClairNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.ORCID 0000-0002-2746-5938
Samuel A KotlerNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Pranav ShahNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.ORCID 0000-0003-0076-7159
Elias Carvalho PadilhaNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Yuhong FangNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
David CalabreseNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Emmett R GeorgeNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.ORCID 0000-0002-9026-9390
Amy WangNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Xin XuNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Elena BarnaevaNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Marc FerrerNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Mark HendersonNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Irina AgoulnikDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States.ORCID 0000-0003-4889-0324
Alexander I AgoulnikDepartment of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 11200 SW Eighth Street, HLSI 419B, Miami, Florida 33199, United States.
Juan J MaruganNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.ORCID 0000-0002-3951-7061

Funding

Small molecule agonists of insulin-like3 receptor for treatment of osteoporosisR01AR070093 · NIAMS · FLORIDA INTERNATIONAL UNIVERSITY · PI AGOULNIK, ALEXANDER I · 2016 to 2018
$885k
Intramural NIH HHS Z99 TR999999NIAMS NIH HHS R01 AR070093
6 · The paper itself

Abstract

A dose-response quantitative high-throughput screening of 147,334 small molecule compounds using a human Relaxin/Insulin-like Family Peptide Receptor 2 (RXFP2)-transfected HEK293T-RXFP2 cell line identified compound

Indexed as

Receptors, G-Protein-CoupledReceptors, PeptideSmall Molecule LibrariesAnimalsHEK293 CellsHumansInsulinInsulin-Like PeptidesMiceProteinsRatsRelaxinStructure-Activity RelationshipInsulinInsulin-Like PeptidesLeydig insulin-like proteinProteinsReceptors, G-Protein-CoupledReceptors, PeptideRelaxinRXFP2 protein, humanSmall Molecule Libraries

Identifiers

PMID41710979
PMCPMC13631973

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.