Mustn1 ablation in male mice results in fiber type and gene expression alterations during skeletal muscle regeneration.

Kaitlin Tagliaferri, Nithya Thomas, Michael Atallah, Stavroula Triantafillou, Michael Hadjiargyrou

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In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Kaitlin TagliaferriCollege of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York, USA.

Nithya ThomasCollege of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York, USA.

Michael AtallahCollege of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York, USA.

Stavroula TriantafillouCollege of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York, USA.

Michael HadjiargyrouCollege of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York, USA.ORCID 0000-0001-8927-2333

Funding

The Role of Mustn1 in Cartilage BiologyR15HD092931 · NICHD · NEW YORK INST OF TECHNOLOGY · PI HADJIARGYROU, MICHAEL · 2017 to 2017

$442k

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R15HD092931New York Institute of Technology (NYIT)

6 · The paper itself

Abstract

We previously developed a Mustn1 conditional knockout (KO) mouse model targeting Pax7-expressing skeletal muscle satellite cells and showed its role in glucose metabolism, strength, gait, peak contractile strength, and myofiber composition. To investigate Mustn1's role in muscle regeneration, we used these KO mice in a cardiotoxin (CTX)-induced tibialis anterior injury model. Despite no major histological differences or deficits in ladder climbing between KO and wild-type (WT) mice at post-injury (Day 2-10), we observed significant shifts in fiber type composition. Mustn1 KO mice had more Type IIa fibers at Day 5, while Type IIx and IIb fibers were reduced at Day 2 and 10, respectively. Additionally, we observed increases in Type I fiber cross-sectional area in the Mustn1 KO mice at Day 0 and 2. Lower numbers of centrally nucleated fibers were also seen in the Mustn1 KO mice at Day 10. Pax7

Indexed as

Muscle Fibers, SkeletalMuscle, SkeletalRegenerationAnimalsCardiotoxinsMaleMiceMice, KnockoutPAX7 Transcription FactorCardiotoxinsPAX7 Transcription Factorcardiotoxinfiber‐typeMustn1regenerationskeletal muscle

Identifiers

PMID41711147

DOI10.14814/phy2.70772

PMCPMC12917859

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.