ArticleESC heart failure2026
Basal inferoseptal longitudinal strain deformation may indicate early cardiac involvement in wild-type carpal ATTR.
Article in ESC heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
aimsWild-type transthyretin cardiac amyloidosis (ATTRwt-CA) is now increasingly identified as a cause of heart failure in older adults. This study aimed to clarify the morphological and functional alterations of the left ventricle (LV) that define the early stage of this condition.
methodsWe prospectively evaluated 81 patients diagnosed with wild-type ATTR (ATTRwt) amyloidosis (mean age 77 ± 6 years; 88% male), categorized into three groups based on myocardial uptake on radioactive pyrophosphate scintigraphy and histological confirmation: (i) carpal ATTR without cardiac involvement (Group 1, n = 13), (ii) asymptomatic cardiac involvement (Group 2, n = 10) and (iii) overt heart failure (Group 3, n = 58).
resultsCompared with Group 3, Group 1 showed higher absolute global longitudinal strain (GLS) (median 19.0 [13.2-23.8]%, P < .001), a lower apical-sparing ratio (median 0.66 [0.55-1.04], P < .001) and lower brain natriuretic peptide (BNP) (median 13.5 [6-49] pg/mL, P < .001) and troponin-T concentrations (0.012 [0.006-0.022] ng/mL, P < .001), while the estimated glomerular filtration rate remained preserved (64 ± 9 mL/mL/1.73 m², P = .022). Segmental longitudinal strain (LS) differentiated Group 1 from Group 2, with basal inferoseptal LS significantly lower in patients with elevated troponin-T (> 0.014 ng/mL) than in those with lower values (13.9 ± 5.6% vs. 7.4 ± 1.8%, P = .046) in Group 1. A basal inferoseptal LS cutoff of 9.1% identified high troponin-T with an area under the curve (AUC) of 0.833 (P = .005), outperforming GLS (AUC 0.306, P = .217), BNP (AUC 0.667, P = .292), and LV ejection fraction (AUC 0.556, P = .743).
conclusionsBasal inferoseptal LS impairment may indicate early cardiac involvement in individuals with carpal tunnel syndrome carrying ATTRwt deposits.
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