Evidence map›Paper›PMID 41711348›Full record

ArticleJournal of the American Chemical Society2026

Structural Change of ApoE-Lipid Nanoparticles Alters Receptor-Mediated Endocytosis and Induces Endosomal Disruption.

Yulin Mo, Heyi Liu, Alexander F A Keszei, David L Dai, Ali Makky, Lili Ding, Anni Pan, Jiachuan Bu, Mohammad T Mazhab-Jafari, Juan Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yulin MoInstitute of Medical Science, University of Toronto, Toronto, Ontario M5G 1L7, Canada.ORCID 0009-0006-7716-905X
Heyi LiuPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Alexander F A KeszeiPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
David L DaiPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Ali MakkyUniversité Paris-Saclay, CNRS, Institut Galien Paris-Saclay, Bâtiment Henri Moissan, Orsay 91400, France.ORCID 0000-0002-3807-0886
Lili DingPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Anni PanPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Jiachuan BuPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Mohammad T Mazhab-JafariPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Juan ChenPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Gang ZhengInstitute of Medical Science, University of Toronto, Toronto, Ontario M5G 1L7, Canada.ORCID 0000-0002-0705-7398

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apolipoprotein E (ApoE) is a key regulator of lipid metabolism that binds to lipid nanoparticle (LNP) surfaces to mediate cellular interactions. However, the ApoE-LNP behavior is highly dependent on the LNP composition, and the underlying mechanisms remain unclear. Here, we show that subtle alterations in LNP surface lipids profoundly reshape the ApoE-LNP structure and intracellular trafficking. Using cryogenic electron microscopy and live-cell imaging, we demonstrate that replacing 10 mol % 1,2-distearoyl-

Indexed as

Apolipoproteins EEndocytosisEndosomesLipidsNanoparticlesHumansLiposomesApolipoproteins ELipid NanoparticlesLipidsLiposomes

Identifiers

PMID41711348
PMCPMC12964400

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.