ArticleJournal of extracellular vesicles2026
A Sensitive Reporter Mouse Model to Study Adipocyte-Derived Extracellular Vesicles In Vivo.
Article in Journal of extracellular vesicles, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Engineering extracellular vesicle biogenesis for therapeutic gene delivery: emerging genetic programming strategies and translational prospects.Molecular biology reports · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Extracellular vesicles (EVs) affect the function of cells in living animals. Yet, cell type-specific EV abundances and their distribution in biological fluids are technically challenging to study. Thus, we aimed to develop an in vivo EV reporter system to monitor cell-type-specific EVs, with a focus on adipocyte-derived EVs. While our previously generated EV reporter construct had insufficient sensitivity, we successfully created a sensitive EV reporter using an adeno-associated virus (AAV) vector with Cre-activated expression of human CD63 fused to NanoLuc (CD63-NanoLuc). Moreover, we designed a control AAV construct for monitoring constitutive secretion of NanoLuc (sec-NanoLuc). AAV administration to mice induced adipocyte-specific expression of both reporters. NanoLuc activity was detected in plasma. While sec-NanoLuc was predominantly in plasma and urine, CD63-NanoLuc was highest in adipose tissues (ATs). We challenged mice with a 2-week high-fat diet (HFD), which had minimal effects on body weight and adipogenic markers. Still, the HFD-fed CD63-NanoLuc mice, but not sec-NanoLuc mice, showed significantly higher NanoLuc activity in ATs, lungs, kidneys and urine. Thus, our CD63-NanoLuc and sec-NanoLuc constructs revealed an early effect of HFD on the abundance and distribution of adipocyte-derived EVs and provide a sensitive system for monitoring cell-type-specific EVs in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.