Evidence map›Paper›PMID 41711708›Full record

ArticleESC heart failure2026

Atrial fibrillation increases left and right atrial pressures in patients with chronic heart diseases.

Davide Genovese, Michele Strosio, Enrico Fantini, Giacomo Prete, Marco Previtero, Carlo Cernetti, Giuseppe Tarantini, Domenico Corrado, Martina Perazzolo Marra

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In one paragraph

Article in ESC heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Davide GenoveseCardiology Unit, Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, Via Giustiniani, 2, Padova 35128, Italy.ORCID 0000-0002-8814-0969
Michele StrosioCardiology Unit, Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, Via Giustiniani, 2, Padova 35128, Italy.
Enrico FantiniCardiology Unit, Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, Via Giustiniani, 2, Padova 35128, Italy.
Giacomo PreteCardiology Unit, Cardio-Neuro-Vascular Department, Ca' Foncello Hospital, Piazzale Ospedale, 1, Treviso 31100, Italy.
Marco PreviteroCardiology Unit, Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, Via Giustiniani, 2, Padova 35128, Italy.
Carlo CernettiCardiology Unit, Cardio-Neuro-Vascular Department, Ca' Foncello Hospital, Piazzale Ospedale, 1, Treviso 31100, Italy.
Giuseppe TarantiniCardiology Unit, Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, Via Giustiniani, 2, Padova 35128, Italy.ORCID 0000-0002-5055-2917
Domenico CorradoCardiology Unit, Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, Via Giustiniani, 2, Padova 35128, Italy.ORCID 0000-0003-1487-0392
Martina Perazzolo MarraCardiology Unit, Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, Via Giustiniani, 2, Padova 35128, Italy.ORCID 0000-0001-7645-6993

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPulmonary capillary wedge pressure (PCWP) and right atrial pressure (RAP) are key haemodynamic indicators of cardiac congestion. Atrial fibrillation (AF) often coexists with several heart diseases, making it challenging to determine AF's independent contribution to atrial pressure elevation. Therefore, the impact of AF on PCWP and RAP requires clarification. We sought to quantify the contribution of AF on PCWP and RAP within patients with various chronic heart diseases.

methodsWe performed a single-center retrospective analysis on 1452 patients (age: 68.0 ± 13.6 years, 58.7% male, 26% AF) with chronic heart diseases undergoing right heart catheterization (RHC). PCWP and RAP were measured during RHC, and the underlying AF or sinus rhythm (SR) was annotated. To isolate AF effect from clinical, haemodynamic, and echocardiographic confounders, two propensity score matching analyses yielded two balanced cohorts for PCWP (n = 496) and RAP (n = 494) analysis.

resultsAfter matching, PCWP was higher in the AF than the SR group (18.4 ± 0.49 mmHg vs 15.7 ± 0.49 mmHg; P < .001). Similarly, RAP was higher in the AF than the SR group (8.7 ± 0.34 mmHg vs 7.5 ± 0.34 mmHg; P = .02). The findings were highly robust for PCWP (E-value = 10.8) and moderately robust for RAP (E-value = 2.78) to unmeasured confounders. Additionally, patients in the SR cohort with a prior history of AF had significantly higher PCWP and RAP compared to patients with no AF history.

conclusionIn our cohort, AF increased PCWP by 2.6 mmHg and RAP by 1.1 mmHg. Furthermore, a previous history of AF is linked to higher atrial pressures in patients later in SR.

Indexed as

Atrial FibrillationAtrial Function, RightAtrial PressureHeart AtriaHeart DiseasesPulmonary Wedge PressureAgedCardiac CatheterizationChronic DiseaseEchocardiographyFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesAtrial fibrillationHeart failureLeft atrial pressurePulmonary capillary wedge pressureRight atrial pressureRight heart catheterization

Identifiers

PMID41711708
PMCPMC13108304

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.