Evidence map›Paper›PMID 41711713›Full record

ReviewESC heart failure2026

Interplay between medical and interventional therapies in valvular heart disease and heart failure: an expert opinion paper.

Matteo Pagnesi, Mauro Riccardi, Francesco Maisano, Elena-Laura Antohi, Vassilis Barberis, Magdy Abdelhamid, Henrike Arfsten, Julia Grapsa, Nicole Karam, Denisa Muraru and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ESC heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Matteo PagnesiDepartment of Medical and Surgical Specialties, Institute of Cardiology, ASST Spedali Civili, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.ORCID 0000-0002-9298-7871
Mauro RiccardiInstitute of Cardiology, ASST Cremona, Cremona, Italy.ORCID 0009-0009-3444-1916
Francesco MaisanoDepartment of Cardiac Surgery, San Raffaele Scientific Institute, Milan, Italy.
Elena-Laura AntohiDepartment of Cardiology, Emergency Institute for Cardiovascular Diseases 'Prof. C.C. Iliescu', Bucharest, Romania.
Vassilis BarberisAmerican Medical Center, American Heart Institute, Nicosia, Cyprus.
Magdy AbdelhamidFaculty of Medicine, Department of Cardiovascular Medicine, Kasr Al Ainy, Cairo University, Giza, Egypt.ORCID 0000-0002-6701-7072
Henrike ArfstenDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Julia GrapsaHeart and Vascular Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4620-6234
Nicole KaramCardiology Department, Clemenceau Medical Center, Balamand University, Beirut, Lebanon.ORCID 0000-0002-3861-6914
Denisa MuraruDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.ORCID 0000-0003-2514-3668
Karl-Philipp RommelDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.ORCID 0000-0002-2901-8138
Anna SanninoDepartment of Cardiology, Deutsches Herzzentrum der Charité, Berlin, Germany.
Wilfried MullensDepartment of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium.ORCID 0000-0001-9995-8590
Marianna AdamoDepartment of Medical and Surgical Specialties, Institute of Cardiology, ASST Spedali Civili, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.ORCID 0000-0002-3855-1815
Marco MetraVita-Salute San Raffaele University, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure (HF) and valvular heart disease (VHD) often coexist and share complex pathophysiological pathways. Traditional management strategies follow a step-by-step approach, prioritizing guideline-directed medical therapy (GDMT) and reserving interventional (surgical or percutaneous) options only in case of persistent symptoms or worsening HF after GDMT. However, greater experience with the use of percutaneous procedures, even in high-risk patients, could support a more integrated approach, which exploits the synergistic effects of medical and interventional therapies to increase the tolerability of one vs the other, thereby improving quality of life and outcomes through their synergic effects. This expert opinion paper summarizes current data and evolving practices in the management of VHD in patients with HF, including secondary mitral regurgitation, aortic stenosis, aortic regurgitation, and tricuspid regurgitation.

Indexed as

Disease ManagementHeart FailureHeart Valve DiseasesQuality of LifeHumansAortic regurgitationAortic stenosisHeart failureMitral regurgitationTricuspid regurgitationValvular heart disease

Identifiers

PMID41711713
PMCPMC13108286

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.