ArticleESC heart failure2026
Non-invasive cardiovascular magnetic resonance pulmonary capillary wedge pressure predicts future atrial fibrillation: a LOOP substudy.
Article in ESC heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- MRI staging of haemodynamic congestion and clinical outcomes.European radiology · 2026Article
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11 authors.
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Abstract
introductionElevated pulmonary capillary wedge pressure (PCWP) is known to drive atrial fibrillation (AF). However, it remains unknown if non-invasive cardiovascular magnetic resonance (CMR)-derived PCWP could predict the future risk of AF. This study investigated whether a CMR-derived measure of PCWP could predict future AF.
methodsWe enrolled 202 participants (mean age 76.2 ± 4.2 years) from the LOOP study, each receiving implantable loop recorder for continuous rhythm monitoring over 4 years. Cardiovascular magnetic resonance imaging quantified left atrial volume (LAV) and left ventricular mass, allowing calculation of a validated sex-specific equation derived PCWP. Cox proportional hazards analysis identified independent variables associated with incident AF.
resultsEighty-six participants (42.6%) manifested AF during follow-up. Individuals with AF exhibited significantly higher CMR-PCWP (16.1 ± 2.8 vs 14.7 ± 2.3 mmHg, P < .01) and greater LAV. Univariate regression highlighted that PCWP ≥16 mmHg was significantly associated with incident AF [hazard ratio (HR): 2.73]. Stepwise Cox regression confirmed that PCWP ≥16 mmHg and the CHARGE-AF score remained independently associated with AF, with PCWP conveying higher HR (2.88, P < .001). Kaplan-Meier analysis reinforced the importance of this threshold for AF onset, demonstrating a significantly increased probability of arrhythmia over time and emphasizing its decisive clinical impact.
conclusionElevated CMR-PCWP is associated with AF in older, high-stroke-risk individuals, underscoring the role of subclinical diastolic dysfunction in promoting arrhythmogenesis. Incorporating non-invasive PCWP assessment into routine CMR evaluation may enhance risk stratification, allowing prompt identification of at-risk patients and enabling earlier, precise, targeted measures for AF prevention.
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