Evidence map›Paper›PMID 41712894›Full record

ReviewJACC. Asia2026

Drivers of Atherosclerotic Cardiovascular Disease in South Asians: Current Insights and Future Directions.

Aayush Patel, Stephen J Nicholls, Derek P Chew, Andrew K Lin, Pradeep Natarajan, Adam J Nelson, Nitesh Nerlekar

Abstract readReview
In one paragraph

Review in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aayush PatelDepartment of Cardiology, The Northern Hospital, Epping, Melbourne, Victoria, Australia.
Stephen J NichollsVictorian Heart Institute, Monash University, Melbourne, Victoria, Australia; Department of Cardiology, Victorian Heart Hospital, Melbourne, Victoria, Australia.
Derek P ChewVictorian Heart Institute, Monash University, Melbourne, Victoria, Australia; Department of Cardiology, Victorian Heart Hospital, Melbourne, Victoria, Australia.
Andrew K LinVictorian Heart Institute, Monash University, Melbourne, Victoria, Australia; Department of Cardiology, Victorian Heart Hospital, Melbourne, Victoria, Australia; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Pradeep NatarajanCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Center for Genomic Medicine and Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Adam J NelsonVictorian Heart Institute, Monash University, Melbourne, Victoria, Australia; Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia.
Nitesh NerlekarVictorian Heart Institute, Monash University, Melbourne, Victoria, Australia; Department of Cardiology, Victorian Heart Hospital, Melbourne, Victoria, Australia; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. Electronic address: nitesh.nerlekar@monash.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerotic cardiovascular disease remains a leading cause of morbidity and mortality, with South Asians experiencing a disproportionately high burden. This excess risk is not fully explained by conventional risk factors, highlighting the need for a more nuanced understanding. However, progress has been hindered by a paucity of South Asian-specific research, limited validation studies, and under-representation in clinical trials. Emerging evidence points to a complex interplay of genetic predisposition, cardiometabolic dysfunction, lifestyle, and socioeconomic influences driving this heightened susceptibility. This review synthesizes recent advancements in genomics, lipid metabolism, biomarkers, imaging, and composite risk calculators, aiming to refine risk stratification in clinical practice. Additionally, we discuss key limitations in current research and explore future directions to bridge knowledge gaps. A deeper understanding of these factors is essential to developing targeted interventions and identifying novel therapeutic strategies to attenuate the elevated atherosclerotic cardiovascular disease risk.

Indexed as

cardiovascular riskreviewSouth Asian

Identifiers

PMID41712894
PMCPMC13491095

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.