Evidence map›Paper›PMID 41713416›Full record

ArticleCell2026

Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury.

Yu Kang T Xu, Abigail Bush, Ephraim Musheyev, Jacob Umans, Lingzi Zhang, Anya A Kim, Sen Zhang, Jaime Eugenin von Bernhardi, Yuqing Yan, Jeremias Sulam and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Heterochronous laminar maturation in the human prefrontal cortex.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu Kang T XuDepartment of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA; Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Abigail BushDepartment of Neuroscience, Oregon Health & Science University, Portland, OR, USA.
Ephraim MusheyevDepartment of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Jacob UmansDepartment of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Lingzi ZhangDepartment of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Anya A KimDepartment of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Sen ZhangDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Jaime Eugenin von BernhardiDepartment of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Yuqing YanDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA.
Jeremias SulamKavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Dwight E BerglesDepartment of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. Electronic address: dbergles@jhmi.edu.

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
Boss: A cloud-based data archive for electron microscopy and x-ray microtomographyR24MH114785 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BROCK A. WESTER · 2018 to 2026
$6.9M
The Role of KV1.3 in Effector T cellsR01NS041435 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI CALABRESI, PETER A · 2000 to 2025
$5.8M
Mechanisms by which effector T cells modulate endogenous remyelinationR37NS041435 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CALABRESI, PETER A · 2013 to 2019
$3.0M
Aging dependent transformation of oligodendrocyte precursor cellsR01AG072305 · NIA · JOHNS HOPKINS UNIVERSITY · PI BERGLES, DWIGHT E, GOFF, LOYAL ANDREW · 2021 to 2025
$2.0M
The role of oligodendrocyte precursor cells in circuit remodeling in the mature brainF30AG084193 · NIA · JOHNS HOPKINS UNIVERSITY · PI KIM, ANYA · 2023 to 2025
$161k
NIA NIH HHS F30 AG084193NIA NIH HHS R01 AG072305NIGMS NIH HHS T32 GM136577NIMH NIH HHS R24 MH114785NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS041435NINDS NIH HHS R37 NS041435
6 · The paper itself

Abstract

Insulating sheaths of myelin accelerate neuronal communication in the mammalian brain. Oligodendrocytes that produce myelin are generated throughout life to gradually increase myelin coverage, but these dynamics have not been defined brain-wide across the lifespan. We developed a cellular mapping pipeline involving tissue clearing, lightsheet microscopy, and AI-assisted analysis to identify the precise location of millions of oligodendrocytes and assess regional myelin density in the mouse brain. These atlases revealed the diversity of oligodendrocyte patterning, which was consistent between brain hemispheres, individuals, and sexes but displayed both age- and region-specific differences. Integration of these atlases with transcriptomic and ultrastructural datasets highlighted underlying mechanisms that may control this patterning. In models of demyelination and disease, we identified regions of enhanced oligodendrocyte resilience and vulnerability and white matter injury near β-amyloid plaques, demonstrating the utility of this pipeline for defining brain-wide oligodendrocyte dynamics in both health and disease.

Indexed as

BrainBrain MappingMyelin SheathOligodendrogliaAnimalsDemyelinating DiseasesFemaleMaleMiceMice, Inbred C57BLWhite MatteragingAlzheimer's diseasebrain mappingdeep learningdemyelinationlightsheet microscopymyelinoligodendrocyteoligodendrogenesistissue clearing

Identifiers

PMID41713416
PMCPMC12927616

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.