Evidence map›Paper›PMID 41713704›Full record

ReviewGastroenterology2026

Rome V Pediatric Upper Gastrointestinal Disorders of Gut-Brain Interaction.

Rachel Rosen, Osvaldo Borrelli, Christophe Faure, Katja Karrento, Usha Krishnan, Samuel Nurko, Nathalie Rommel, Alan Silverman, Michiel van Wijk, Marc Benninga

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rachel RosenCenter for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology, Children's Hospital Boston, Boston, Massachusetts. Electronic address: rachel.rosen@childrens.harvard.edu.
Osvaldo BorrelliDepartment of Pediatric Gastroenterology, Division of Neurogastroenterology and Motility, Great Ormond Street Hospital, London, United Kingdom.
Christophe FaureDivision of Pediatric Gastroenterology, Hôpital Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.
Katja KarrentoDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Medical College of Wisconsin, Milwaukee, Wisconsin.
Usha KrishnanSchool of Clinical Medicine, Discipline of Paediatrics and Child Health, University of New South Wales, Sydney, Australia; Department of Pediatric Gastroenterology, Sydney Children's Hospital, Randwick, Sydney, New South Wales, Australia.
Samuel NurkoCenter for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology, Children's Hospital Boston, Boston, Massachusetts.
Nathalie RommelDepartment of Gastroenterology, Neurogastroenterology and Motility, University Hospitals Leuven, Leuven, Belgium; Department of Neurosciences, Experimental Otorhinolaryngology, Deglutology, University of Leuven, Leuven, Belgium.
Alan SilvermanDepartment of Pediatrics, Division of Pediatric Psychology & Developmental Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Michiel van WijkDepartment of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, the Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism & Amsterdam Reproduction and Development Research Institutes, Amsterdam UMC, VU University, Amsterdam, the Netherlands.
Marc BenningaDepartment of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, the Netherlands.

Funding

The impact of upper gastrointestinal dysmotility on aspiration-associated aerodigestive disorders in childrenR01DK097112 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Rachel L Rosen · 2015 to 2026
$4.9M
NIDDK NIH HHS R01 DK097112
6 · The paper itself

Abstract

Upper gastrointestinal disorders of gut-brain interaction (DGBI) present from infancy through adolescence. The Rome V Criteria have expanded to include DGBI of the esophagus, disorders of air-transit, and feeding disorders, as well as rumination syndrome, cyclic vomiting, chronic nausea syndrome, and functional dyspepsia. This expansion provides a diagnostic framework for patients presenting with chest and throat pain, feeding difficulties, belching, pain with eating, nausea, and vomiting. Given the advances in impedance technology and high-resolution manometry, testing plays a greater role in many of these diagnostic criteria than they have in past Rome iterations. This harmony between symptoms and testing results in more precision in therapeutic approaches that are critically multidisciplinary. The ability to assign new, positive diagnoses across the upper gastrointestinal tract offers new opportunities for pediatric-focused therapeutic trials.

Indexed as

BrainBrain-Gut AxisGastrointestinal DiseasesUpper Gastrointestinal TractAdolescentChildChild, PreschoolHumansInfantManometryVomitingFeeding DisordersGastroesophageal RefluxNeuromodulatorsPediatrics

Identifiers

PMID41713704
PMCPMC13202739

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.