Evidence map›Paper›PMID 41713777›Full record

ArticleChest2026

The Impact of Weight Loss on the Physiological Endotypes Associated With OSA.

Caroline J Beatty, Ai-Ming Wong, Shane A Landry, Luke D J Thomson, Jinny Collet, Veronica Odeke, Simon A Joosten, Julie Playfair, Atul Malhotra, Kirk Kee and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Reply to "From coexistence to causation: defining adiposity-attributable obstructive sleep apnea".Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Caroline J BeattyDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.
Ai-Ming WongMonash Lung, Sleep, Allergy and Immunology, Monash Health, Melbourne, VIC, Australia; School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.
Shane A LandryDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.
Luke D J ThomsonDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.
Jinny ColletDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.
Veronica OdekeDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.
Simon A JoostenMonash Lung, Sleep, Allergy and Immunology, Monash Health, Melbourne, VIC, Australia; School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.
Julie PlayfairMonash University Department of Surgery, Alfred Health, Melbourne, VIC, Australia.
Atul MalhotraDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego (UCSD), CA.
Kirk KeeSchool of Translational Medicine, Monash University, Melbourne, VIC, Australia; Department of Respiratory and Sleep Disorders Medicine, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
Matthew T NaughtonSchool of Translational Medicine, Monash University, Melbourne, VIC, Australia; Department of Respiratory Medicine, Alfred Hospital, Melbourne, VIC, Australia.
Kate SutherlandSleep Research Group, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia; Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, NSW, Australia.
Peter A CistulliSleep Research Group, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia; Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, NSW, Australia.
Sanjay R PatelDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Wendy A BrownMonash University Department of Surgery, Alfred Health, Melbourne, VIC, Australia.
Garun S HamiltonMonash Lung, Sleep, Allergy and Immunology, Monash Health, Melbourne, VIC, Australia; School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.
Bradley A EdwardsDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia. Electronic address: bradley.edwards@monash.edu.

Funding

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
A randomized trial of bariatric surgery for the treatment of sleep apneaR01HL106410 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI PATEL, SANJAY R · 2010 to 2013
$2.6M
Developing a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander, Atul Malhotra · 2023 to 2026
$1.6M
NHLBI NIH HHS R01 HL106410NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL166127NIA NIH HHS R01 AG063925
6 · The paper itself

Abstract

backgroundWeight loss improves upper airway collapsibility in people with OSA. However, it is unclear how weight loss affects the other physiological traits (ie, endotypes) associated with OSA (loop gain, arousal threshold, and muscle compensation). RESEARCH QUESTIONS: What is the effect of metabolic bariatric surgery on the OSA endotypes, and are the baseline endotypes associated with improvements in OSA severity? STUDY DESIGN AND

methodsUsing noninvasive methods, the OSA endotypes were measured during overnight clinical polysomnography in 43 patients before and after (approximately 6-18 months) metabolic bariatric surgery. OSA endotypes were also measured, using reference standard physiological techniques (ie, CPAP dial-down method) in a subset of patients (n = 10). Generalized linear mixed-effects models were used to evaluate the effect on outcome variables.

resultsMetabolic bariatric surgery was associated with improvements in apnea-hypopnea index (AHI; 50.7 ± 26.8 vs 24.6 ± 19.2 events/h; P < .001), BMI (42.1 ± 5.5 vs 32.8 ± 4.5 kg/m

interpretationOur results show that metabolic bariatric surgery is associated with improvements in weight, AHI, upper airway collapsibility, and loop gain and may be particularly effective for those with mild upper airway collapsibility and low loop gain.

Indexed as

Bariatric SurgerySleep Apnea, ObstructiveWeight LossAdultBody Mass IndexFemaleHumansMaleMiddle AgedPolysomnographySeverity of Illness Indexendotypesmetabolic bariatric surgeryobstructive sleep apneapathophysiologyweight loss

Identifiers

PMID41713777
PMCPMC13384779

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.